CMAUP Plant Collective Molecular Activities

Plant Name: Scabiosa comosa

Taxonomic Information:

Plant ID: NPO14327
Plant Latin Name: Scabiosa comosa
Taxonomy Genus: Scabiosa
Taxonomy Family: Caprifoliaceae

Plant External Links:

NCBI TaxonomyDB: 1161150
Plant-of-the-World-Online: 319797-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China; Russia; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF;
Enzyme_unclassified	RECQL; HSD11B1; AKR1B10;
Protein Kinase	PRKCA;
Lyase	CA1; CA12; CA5B; CA5A; CA6;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Metallo protease	MMP12; MMP2;
ATP-binding cassette	ABCC1;
Unclassified	HTT; LMNA;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCC1	Multidrug resistance-associated protein 1	P33527	CHEMBL3004
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	7.063E-12	7.689E-08	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0005488; binding	GO:0008270; zinc ion binding	8.952E-11	6.498E-07	CA1, CA12, CA5A, CA5B, CA6, L3MBTL1, MMP12, MMP2, NR1H4, PRKCA, PTPN1, RORC
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.707E-10	4.740E-06	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.491E-09	1.085E-05	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.284E-07	6.218E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	5.944E-07	1.294E-03	AKR1B10, CYP1A1, CYP1A2, CYP1B1, HSD11B1, NR1H4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.508E-06	4.551E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	3.334E-06	4.822E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.334E-06	4.822E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	4.821E-06	4.832E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	4.821E-06	4.832E-03	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	7.560E-06	7.158E-03	ACP1, PTPN1, PTPN2, PTPRF
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	9.634E-06	7.770E-03	PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	9.634E-06	7.770E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.622E-05	1.842E-02	CYP1A1, CYP1A2, CYP1B1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.221E-11	1.111E-09	CA12, CA1, CA5B, CA5A, CA6
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7.696E-07	3.501E-05	HSD11B1, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.949E-06	5.913E-05	HSD11B1, CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.109E-06	7.073E-05	HSD11B1, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.653E-05	3.009E-04	CYP1A2, CYP1A1, CYP1B1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.055E-04	1.600E-03	PTPN1, ACP1, PTPRF
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.771E-03	2.303E-02	CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.973E-03	3.382E-02	CYP1A2, CYP1A1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	5.854E-03	5.158E-02	ABCC1, CYP1B1, PRKCA
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	6.235E-03	5.158E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases