Plant Name: Patrinia scabra
Taxonomic Information:
Plant ID: NPO14197
Plant Latin Name: Patrinia scabra
Taxonomy Genus: Patrinia
Taxonomy Family: Caprifoliaceae
Plant External Links:
NCBI TaxonomyDB:
180074
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
ChinaTraditional Medicine System:
TCMGeographical Distribution:
China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| HTR6; | |
| TSHR; | |
| TDP1; RECQL; MTOR; | |
| MT-ND4; | |
| MAPT; PMP22; HTT; GMNN; LMNA; THPO; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2C19; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | MTOR | Serine/threonine-protein kinase mTOR | P42345 | CHEMBL2842 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Oxidoreductase | MT-ND4 | NADH-ubiquinone oxidoreductase chain 4 | P03905 | CHEMBL4499 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Small molecule receptor (family A GPCR) | HTR6 | Serotonin 6 (5-HT6) receptor | P50406 | CHEMBL3371 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | PMP22 | Peripheral myelin protein 22 | Q01453 | CHEMBL1293298 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | GMNN | Geminin | O75496 | CHEMBL1293278 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 2.673E-05 | 3.491E-01 | HTT, MAPT |
| BP | GO:0032501; multicellular organismal process | GO:0055013; cardiac muscle cell development | 1.824E-04 | 5.261E-01 | LMNA, MTOR |
| BP | GO:0007610; behavior | GO:0007611; learning or memory | 5.861E-04 | 5.261E-01 | HTT, MAPT, MTOR |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 1.449E-03 | 6.574E-01 | TSHR |
| CC | GO:0044464; cell part | GO:0030425; dendrite | 1.619E-03 | 6.779E-01 | HTT, MAPT, MTOR |
| MF | GO:0005488; binding | GO:0031072; heat shock protein binding | 2.552E-03 | 8.421E-01 | HTT, MAPT |
| MF | GO:0003824; catalytic activity | GO:0009378; four-way junction helicase activity | 3.619E-03 | 8.585E-01 | RECQL |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 3.112E-03 | 1.045E-01 | HTR6, CYP2C19 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 6.087E-03 | 1.045E-01 | THPO, MTOR |
| 09120 Genetic Information Processing | 09122 Translation | hsa03013 | RNA transport | 7.173E-03 | 1.045E-01 | SMN2, SMN1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 9.498E-03 | 1.045E-01 | HTR6, TSHR |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.154E-02 | 1.152E-01 | CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 4.192E-02 | 1.152E-01 | MTOR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 4.120E-02 | 1.152E-01 | TSHR |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 3.903E-02 | 1.152E-01 | TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 4.911E-02 | 1.152E-01 | MTOR |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 5.054E-02 | 1.152E-01 | CYP2C19 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | HTR6; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | MTOR; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | MTOR; |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Emesis | R11 | HTR6; |
| C00-D49: Neoplasms | Solid tumors | NA | MTOR; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MTOR; |
| C00-D49: Neoplasms | Renal cancer | C64 | MTOR; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MTOR; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | MTOR; |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | HTR6; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | HTR6; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | HTR6; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MTOR; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Dementia | F01-F07 | HTR6; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | HTR6; |
| C00-D49: Neoplasms | Sarcoma | C81-C86 | MTOR; |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MTOR; |
| A00-B99: Certain infectious and parasitic diseases | Dutch elm disease | B81-B83 | MTOR; |
| NA: NA | Coronary artery restenosis | NA | MTOR; |
| C00-D49: Neoplasms | Advanced kidney cancer | C64 | MTOR; |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | MTOR; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | HTR6; |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Organ rejection | D89.8, T86 | MTOR; |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MTOR; |
| C00-D49: Neoplasms | Bladder cancer | C67 | MTOR; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Transplant rejection | D89.8, T86 | MTOR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MTOR; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | MTOR; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | HTR6; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
