CMAUP Plant Collective Molecular Activities

Plant Name: Phagnalon rupestre

Taxonomic Information:

Plant ID: NPO14130
Plant Latin Name: Phagnalon rupestre
Taxonomy Genus: Phagnalon
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 943712
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Israel; Jordan

Traditional Medicine System:

Geographical Distribution:

Israel; Jordan

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR4; FFAR1;
Lyase	CA7; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Enzyme_unclassified	ALOX15; CBR1; AKR1B10; AKR1B1;
Oxidoreductase	XDH;
Unclassified	LMNA; FABP3; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0005506; iron ion binding	6.912E-11	3.763E-07	ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.104E-10	4.008E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.570E-10	9.047E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.450E-09	2.255E-06	AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.127E-09	4.256E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	4.622E-09	5.440E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0020037; heme binding	9.445E-08	8.227E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	2.685E-07	2.016E-04	AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.189E-06	7.848E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0005504; fatty acid binding	1.960E-06	1.185E-03	FABP3, FABP5, FFAR4
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	2.662E-06	1.526E-03	AKR1B1, CYP19A1, CYP1A2, XDH
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	3.993E-06	2.121E-03	CYP19A1, CYP1A1, CYP2C19
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.916E-06	2.489E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	8.786E-06	4.232E-03	AKR1B1, AKR1B10, XDH
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.228E-05	5.687E-03	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0022900; electron transport chain	1.331E-05	6.038E-03	AKR1B1, CYP19A1, CYP1A2, XDH
BP	GO:0008152; metabolic process	GO:0044242; cellular lipid catabolic process	1.724E-05	7.508E-03	AKR1B10, CYP1B1, FABP3, FABP5
BP	GO:0008152; metabolic process	GO:0044597; daunorubicin metabolic process	2.289E-05	8.900E-03	AKR1B1, AKR1B10
BP	GO:0008152; metabolic process	GO:0044598; doxorubicin metabolic process	2.289E-05	8.900E-03	AKR1B1, AKR1B10
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	2.289E-05	8.900E-03	CYP1A1, CYP1A2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	8.412E-09	2.860E-07	CBR1, CYP1A2, CYP1A1, CYP1B1, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.812E-07	4.087E-06	CBR1, AKR1B10, CYP1A2, ALOX15, CYP1A1, AKR1B1, CYP2C19, CYP19A1, XDH
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.890E-07	3.213E-06	CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.808E-07	4.087E-06	CBR1, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.923E-06	3.356E-05	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.168E-05	4.966E-05	CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.204E-06	1.499E-05	CYP1A2, ALOX15, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.239E-05	8.460E-05	CBR1, ALOX15, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.090E-05	1.051E-04	FABP3, FABP5, PPARA
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	1.270E-03	2.878E-03	AKR1B10, AKR1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.539E-03	3.270E-03	CYP1A2, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.732E-03	3.464E-03	CYP1A2, CYP2C19
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4.733E-04	1.149E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	3.279E-04	9.289E-04	AKR1B10, AKR1B1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.485E-03	8.471E-03	ALOX15, CYP2C19
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3.734E-04	9.767E-04	AKR1B10, AKR1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.032E-04	3.190E-04	CA4, CA7
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	7.638E-06	3.710E-05	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
I00-I99: Diseases of the circulatory system	Heart failure	I50	XDH;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH;
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH;
J00-J99: Diseases of the respiratory system	Asthma	J45	CBR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1; FFAR1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1; XDH;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases