CMAUP Plant Collective Molecular Activities

Plant Name: Achyranthes fauriei

Taxonomic Information:

Plant ID: NPO14123
Plant Latin Name: Achyranthes fauriei
Taxonomy Genus: Achyranthes
Taxonomy Family: Amaranthaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM; Kampo

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family C GPCR)	GRM8; GRM1;
Small molecule receptor (family A GPCR)	ADORA3;
Protein Phosphatase	CDC25B;
Ionotropic glutamate receptor	GRIA4; GRIA2; GRIK3; GRIK5; GRIK1;
Enzyme_unclassified	PKM;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
SLC superfamily of solute carriers	SLC1A1;
Unclassified	FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Ionotropic glutamate receptor	GRIA4	Glutamate receptor ionotropic, AMPA 4	P48058	CHEMBL3190
Ionotropic glutamate receptor	GRIA2	Glutamate receptor ionotropic, AMPA 2	P42262	CHEMBL4016
Ionotropic glutamate receptor	GRIK3	Glutamate receptor ionotropic kainate 3	Q13003	CHEMBL3684
Ionotropic glutamate receptor	GRIK5	Glutamate receptor ionotropic kainate 5	Q16478	CHEMBL2675
Ionotropic glutamate receptor	GRIK1	Glutamate receptor ionotropic kainate 1	P39086	CHEMBL1918
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
SLC superfamily of solute carriers	SLC1A1	Excitatory amino acid transporter 3	P43005	CHEMBL2721
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family C GPCR)	GRM8	Metabotropic glutamate receptor 8	O00222	CHEMBL3228
Small molecule receptor (family C GPCR)	GRM1	Metabotropic glutamate receptor 1	Q13255	CHEMBL3772
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005215; transporter activity	GO:0005234; extracellularly glutamate-gated ion channel activity	6.650E-13	3.620E-09	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	3.753E-12	1.634E-08	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	6.317E-10	1.146E-06	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0015277; kainate selective glutamate receptor activity	2.380E-09	3.454E-06	GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0007196; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	1.996E-08	2.668E-05	GRIK3, GRM1, GRM8
BP	GO:0023052; signaling	GO:0051966; regulation of synaptic transmission, glutamatergic	5.498E-08	5.701E-05	GRIK1, GRIK3, GRM1, GRM8
MF	Unclassified;	GO:0004872; receptor activity	7.372E-08	7.296E-05	ADORA3, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5, GRM1, GRM8, NR1H4
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	1.778E-07	1.434E-04	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0008381; mechanosensitive ion channel activity	1.698E-06	8.802E-04	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0004971; AMPA glutamate receptor activity	2.507E-06	1.241E-03	GRIA2, GRIA4
CC	GO:0044456; synapse part	GO:0042734; presynaptic membrane	8.802E-06	3.423E-03	GRIK5, GRM1, GRM8
BP	GO:0051179; localization	GO:0034220; ion transmembrane transport	1.130E-05	4.171E-03	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5, SLC1A1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	3.514E-23	4.814E-21	GRIA2, GRIK5, SLC1A1, GRIK3, GRIK1, GRIK2, GRM1, GRM3, GRM2, GRM5, GRM4, GRM8, MAPK1, GRIA4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.230E-17	8.427E-16	GRIA2, GRIK5, GRIK3, GRIK1, GRIK2, TSHR, GRM1, GRM3, GRM2, GRM5, GRM4, ADORA3, GRM8, GRIA4
09130 Environmental Information Processing	09132 Signal transduction	hsa04072	Phospholipase D signaling pathway	4.921E-09	1.685E-07	GRM3, GRM2, GRM5, GRM4, GRM8, MAPK1, GRM1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.025E-09	9.250E-08	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	8.555E-07	2.344E-05	GRIA2, GRM5, MAPK1, GRM1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	5.243E-06	1.197E-04	GRIA2, GRM5, MAPK1, GRM1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.362E-05	4.623E-04	GRIA2, MAPK1, PPARA, TSHR, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	8.560E-05	1.466E-03	GRM3, GRIA2, GRM2
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	1.569E-04	2.388E-03	GRIA2, MAPK1, GRM1
09150 Organismal Systems	09159 Environmental adaptation	hsa04713	Circadian entrainment	6.086E-04	7.580E-03	GRIA2, MAPK1, GRIA4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	4.866E-04	6.666E-03	GRM5, MAPK1, GRM1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
C00-D49: Neoplasms	Solid tumours	C00-D48	PKM;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	GRM1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	GRM1; GRIK1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	GRM1; GRIK1;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	GRIA2; GRIA4;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	GRM1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	GRM1; GRIK1; PKM;
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3; CDC25B;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	GRM1;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	GRIK1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases