Plant Name: Centaurea zuccariniana
Taxonomic Information:
Plant ID: NPO1406
Plant Latin Name: Centaurea zuccariniana
Taxonomy Genus: Centaurea
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
1486593
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TP53; | |
| SLCO1B3; SLCO1B1; | |
| SMN1;SMN2; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.687E-06 | 3.674E-02 | CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 5.059E-06 | 5.384E-02 | CYP2C19, CYP2C9 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 7.417E-06 | 5.384E-02 | CYP2C19, CYP2C9 |
| MF | GO:0003824; catalytic activity | GO:0008392; arachidonic acid epoxygenase activity | 1.527E-05 | 6.234E-02 | CYP2C19, CYP2C9 |
| MF | GO:0005215; transporter activity | GO:0015125; bile acid transmembrane transporter activity | 1.718E-05 | 6.234E-02 | SLCO1B1, SLCO1B3 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 2.356E-05 | 7.330E-02 | CYP2C19, CYP2C9 |
| MF | GO:0005215; transporter activity | GO:0015347; sodium-independent organic anion transmembrane transporter activity | 3.095E-05 | 8.425E-02 | SLCO1B1, SLCO1B3 |
| BP | GO:0051179; localization | GO:0043252; sodium-independent organic anion transport | 4.236E-05 | 1.025E-01 | SLCO1B1, SLCO1B3 |
| BP | GO:0051179; localization | GO:0015721; bile acid and bile salt transport | 4.873E-05 | 1.061E-01 | SLCO1B1, SLCO1B3 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.106E-04 | 1.721E-01 | CYP2C19, CYP2C9 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 1.876E-03 | 7.857E-01 | SLCO1B1, SLCO1B3 |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 4.065E-02 | 1.000E+00 | CYP2C19, CYP2C9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 4.244E-05 | 2.037E-03 | CYP2C9, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.966E-04 | 3.095E-03 | CYP2C9, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 2.436E-04 | 3.095E-03 | CYP2C9, CYP2C19 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.580E-04 | 3.095E-03 | SLCO1B1, SLCO1B3 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 6.408E-04 | 5.127E-03 | CYP2C9, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 3.441E-04 | 3.303E-03 | CYP2C9, CYP2C19 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 9.984E-04 | 6.846E-03 | LMNA, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 2.528E-02 | 5.346E-02 | TP53 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04115 | p53 signaling pathway | 2.391E-02 | 5.346E-02 | TP53 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 2.528E-02 | 5.346E-02 | CYP2C9 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
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>> Targets derived from weak experimental activities
