CMAUP Plant Collective Molecular Activities

Plant Name: Leucaena leucocephala

Taxonomic Information:

Plant ID: NPO14039
Plant Latin Name: Leucaena leucocephala
Taxonomy Genus: Leucaena
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 3866
Plant-of-the-World-Online: 138955-2

Used in Medicines:

Country/Region:

Qatar; Mexico; Tanzania; Indonesia; India; Rwanda; Thailand; Kenya

Traditional Medicine System:

Indian Folk

Geographical Distribution:

Cambodia; Ethiopia; Swaziland; Argentina; Bolivia; Cameroon; Burkina Faso; Ghana; Cape Verde; Guatemala; Spain; Liberia; Netherlands; Jamaica; Oman; Tanzania; French Guiana; Yemen; Pakistan; India; Kenya; Bangladesh; Mauritania; Rwanda; Somalia; Peru; Laos; Vanuatu; Cote d'Ivoire; Benin; Cuba; Togo; China; Dominican Republic; Indonesia; Mauritius; Vietnam; Mali; United States; Angola; Portugal; South Africa; Cyprus; Qatar; Senegal; Mozambique; Uganda; Japan; Niger; Brazil; Guinea; Costa Rica; Bahamas; Nigeria; Ecuador; Australia; Algeria; El Salvador; Thailand; Haiti; Belize; Sierra Leone; Gambia; Philippines; Namibia; Guinea-Bissau; Seychelles; Chad; Tunisia; Djibouti; Colombia; Burundi; Taiwan; Fiji; Madagascar; Italy; Sudan; Nepal; Maldives; Suriname; Venezuela; Papua New Guinea; Malawi; Zimbabwe; Eritrea; Iraq; New Caledonia; Trinidad and Tobago; Guyana; Honduras; Mexico; Egypt; Congo; Sri Lanka

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	CDC25B;
Lyase	CA2; CA7; CA12; CA1; CA9; CA14;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	GFER;
Unclassified	FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.043E-14	2.224E-10	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.214E-12	1.835E-08	CA1, CA12, CA2, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.235E-07	1.575E-03	CA2, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	9.914E-07	1.963E-03	CA1, CA12, CA2, CA7, CA9, NR1H4
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	3.614E-06	6.054E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.456E-17	3.170E-13	CA1, CA12, CA14, CA2, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.921E-17	3.505E-16	CA12, CA1, CA2, CA7, CA9, CA14
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	5.490E-04	3.294E-03	CA2, NR1H4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B; CA1; CA9;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases