CMAUP Plant Collective Molecular Activities

Plant Name: Xylosma longifolia

Taxonomic Information:

Plant ID: NPO1399
Plant Latin Name: Xylosma longifolia
Taxonomy Genus: Xylosma
Taxonomy Family: Salicaceae

Plant External Links:

NCBI TaxonomyDB: 1603848
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Indian Folk

Geographical Distribution:

India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ACHE;
Protein Kinase	AURKB; AURKA; KDR; CSNK2A1;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Enzyme_unclassified	GFER; HSD17B1;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.084E-09	1.991E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.809E-08	1.313E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.850E-08	1.551E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.145E-07	7.436E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	4.185E-07	7.436E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0020037; heme binding	1.256E-06	1.709E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.507E-06	3.033E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.059E-06	3.172E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	4.177E-06	3.954E-03	AURKA, AURKB
BP	GO:0023052; signaling	GO:0023051; regulation of signaling	5.113E-06	4.124E-03	ACHE, AURKA, AURKB, CSNK2A1, CYP19A1, CYP1B1, ESR2, GFER, KDR, THPO
MF	GO:0003824; catalytic activity	GO:0035174; histone serine kinase activity	6.262E-06	4.545E-03	AURKA, AURKB
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	6.843E-06	4.807E-03	AURKA, AURKB, CSNK2A1, KDR
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.168E-05	7.481E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.286E-05	8.001E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, GFER, HSD17B1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.174E-10	7.391E-09	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.430E-08	4.131E-07	HSD17B1, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.090E-06	2.369E-05	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.300E-05	1.105E-04	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.844E-05	1.254E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7.927E-04	4.492E-03	CYP1A2, CYP1A1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	KDR;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Cancer	C00-C96	AURKA; KDR; CSNK2A1; ACHE;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Breast cancer	C50	KDR; CYP19A1;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	AURKA; AURKB; KDR;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKA; AURKB;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
C00-D49: Neoplasms	Haematological malignancies	C81-C86	AURKA;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
C00-D49: Neoplasms	AML	NA	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	AURKA;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	AURKA;
C00-D49: Neoplasms	Liver cancer	C22	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases