CMAUP Plant Collective Molecular Activities

Plant Name: Fraxinus ornus

Taxonomic Information:

Plant ID: NPO13914
Plant Latin Name: Fraxinus ornus
Taxonomy Genus: Fraxinus
Taxonomy Family: Oleaceae

Plant External Links:

NCBI TaxonomyDB: 38874
Plant-of-the-World-Online: 609128-1

Used in Medicines:

Country/Region:

Turkey; Albania; Italy; India; China; Bulgaria

Traditional Medicine System:

Indian Folk; TCM; Siddha

Medicinal Functions:

Laxative; Tonic

Geographical Distribution:

Turkey; Romania; Albania; Italy; Portugal; India; France; Switzerland; Austria; China; Greece; Belgium; Hungary; Russia; Spain; Bulgaria

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF;
Enzyme_unclassified	ALPI; RECQL; HPGD; HSD11B1; AKR1B10; AKR1B1; GFER; HSD17B10; ALOX15; ALDH1A1; POLB;
Hydrolase	GAA;
Protein Kinase	PRKCA;
Lyase	CA2; CA1; CA12; CA9; CA13; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Cysteine protease	CASP1; CASP7;
Metallo protease	MMP12; MMP2;
Transcription Factor	HIF1A;
Unclassified	LMNA;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	ALPI	Intestinal alkaline phosphatase	P09923	CHEMBL5573
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.721E-13	2.962E-09	CA1, CA12, CA13, CA2, CA4, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.236E-12	5.385E-09	CA1, CA12, CA13, CA2, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.991E-11	1.359E-07	ALPI, CA1, CA12, CA13, CA2, CA4, CA7, CA9, MMP12, MMP2, NR1H4, PRKCA, PTPN1, RORC
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	3.082E-07	5.162E-04	AKR1B1, AKR1B10, ALDH1A1, ALOX15, CYP1A2, GAA, GFER, HPGD, HSD11B1, HSD17B10, XDH
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.164E-06	1.409E-03	AKR1B1, AKR1B10, ALDH1A1, XDH
MF	GO:0003824; catalytic activity	GO:0016616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2.284E-06	2.617E-03	AKR1B1, AKR1B10, HPGD, HSD11B1, HSD17B10
BP	GO:0009987; cellular process	GO:0051716; cellular response to stimulus	4.260E-06	4.538E-03	AKR1B1, ALOX15, CA2, CA9, CASP1, CASP7, CYP1A2, HIF1A, LMNA, MMP2, NR1H4, POLB, PTPN1, PTPRF, RECQL, RORC
BP	GO:0050896; response to stimulus	GO:0010033; response to organic substance	4.396E-06	4.538E-03	AKR1B1, ALOX15, CA2, CA9, CASP1, CASP7, CYP1A2, HIF1A, HPGD, MMP2, NR1H4, POLB, PRKCA, RORC
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	9.558E-06	8.325E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	9.558E-06	8.325E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	9.558E-06	8.325E-03	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0016311; dephosphorylation	1.087E-05	8.764E-03	ACP1, ALPI, POLB, PTPN1, PTPN2, PTPRF
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.154E-16	4.691E-12	CA1, CA12, CA13, CA2, CA4, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.092E-16	5.703E-14	CA12, CA1, CA2, CA4, CA7, CA9, CA13
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.537E-05	9.904E-04	HSD11B1, AKR1B10, GAA, CYP1A2, ALOX15, ALDH1A1, AKR1B1, ALPI, HSD17B10, XDH
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.930E-05	9.904E-04	AKR1B10, GAA, AKR1B1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.923E-04	6.547E-03	PTPN1, ACP1, PTPRF
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.965E-05	9.904E-04	CYP1A2, XDH
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	7.355E-04	1.373E-02	CA2, CA4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.173E-03	1.876E-02	CYP1A2, ALOX15
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1.806E-03	2.247E-02	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.428E-03	1.999E-02	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4.625E-03	4.248E-02	HSD11B1, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases