CMAUP Plant Collective Molecular Activities

Plant Name: Humulus lupulus

Taxonomic Information:

Plant ID: NPO13879
Plant Latin Name: Humulus lupulus
Taxonomy Genus: Humulus
Taxonomy Family: Cannabaceae

Plant External Links:

NCBI TaxonomyDB: 3486
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Turkey; Canada; Italy; Czech Republic; India; Lithuania; France; United States; Germany; China; Russia; Spain

Traditional Medicine System:

TCM; Homeopathy

Medicinal Functions:

Anodyne; Antianxiety; Antibacterial; Antiseptic; Antispasmodic; Appetizer; Diuretic; Febrifuge; Galactogogue; Hypnotic; Nervine; Sedative; Stomachic; Tonic

Geographical Distribution:

Canada; Turkey; Italy; Czech Republic; Lithuania; India; France; United States; Germany; China; Russia; Spain

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	ALPL; TDP1; PIK3CA; PIK3CB; ALOX12; HSD17B2; HSD17B10; NOX4; NQO2; POLB;
Hydrolase	ACHE;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; CDK8; AURKB;
Lyase	CA2; CA12; CA9; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	TYR; PTGS2;
Lysine demethylase	KDM4E;
Transcription Factor	AHR; HIF1A; TP53; NFKB1;
Transferase	FUT7;
SLC superfamily of solute carriers	SLC5A1; SLC5A2; SLC5A4;
Unclassified	LMNA; FABP4;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP19A1; CYP3A4; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	NQO2	Quinone reductase 2	P16083	CHEMBL3959
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PIK3CA	PI3-kinase p110-alpha subunit	P42336	CHEMBL4005
Enzyme_unclassified	PIK3CB	PI3-kinase p110-beta subunit	P42338	CHEMBL3145
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	CDK8	Cell division protein kinase 8	P49336	CHEMBL5719
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
SLC superfamily of solute carriers	SLC5A1	Sodium/glucose cotransporter 1	P13866	CHEMBL4979
SLC superfamily of solute carriers	SLC5A2	Sodium/glucose cotransporter 2	P31639	CHEMBL3884
SLC superfamily of solute carriers	SLC5A4	Low affinity sodium-glucose cotransporter	Q9NY91	CHEMBL1770047
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.388E-12	3.022E-08	CA12, CA14, CA2, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.825E-11	2.051E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, NOX4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.845E-09	2.678E-06	CA12, CA14, CA2, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0020037; heme binding	1.757E-09	2.678E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, NOX4, PTGS2
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.765E-09	4.314E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	9.688E-09	6.592E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.108E-08	2.130E-05	CA12, CA2, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.295E-07	1.009E-04	ALOX12, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.701E-07	1.153E-04	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.659E-07	1.423E-04	CYP1A2, CYP2C19, CYP3A4
MF	GO:0005215; transporter activity	GO:0005412; glucose:sodium symporter activity	3.659E-07	1.423E-04	SLC5A1, SLC5A2, SLC5A4
MF	GO:0005488; binding	GO:0043560; insulin receptor substrate binding	2.990E-06	8.457E-04	IGF1R, PIK3CA, PIK3CB
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.980E-06	1.097E-03	CYP1A2, CYP2C19, CYP3A4
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	4.114E-06	1.120E-03	ALPL, CYP1A1, CYP1B1, ESR1, FLT3, NFKB1, NOX4, PTGS2
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	7.108E-06	1.739E-03	ESR1, ESR2
BP	GO:0009987; cellular process	GO:0055082; cellular chemical homeostasis	8.087E-06	1.854E-03	CA2, CA7, ESR1, HIF1A, NOX4, NPSR1, NR1H4, PIK3CA, PIK3CB, TP53
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	8.910E-06	1.970E-03	ALPL, AXL, CYP1A1, CYP1A2, NFKB1, NR1H4, PTGS2
BP	GO:0008152; metabolic process	GO:0008610; lipid biosynthetic process	1.486E-05	2.839E-03	ACHE, ALOX12, CYP19A1, CYP1A1, CYP3A4, HSD17B2, PIK3CA, PIK3CB, PTGS2
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.129E-05	3.747E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	2.129E-05	3.747E-03	CYP1A1, CYP3A4
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	2.365E-05	4.023E-03	CYP1A1, POLB, TP53
BP	Unclassified;	GO:0035428; hexose transmembrane transport	2.733E-05	4.413E-03	SLC5A1, SLC5A2, SLC5A4
BP	GO:0051179; localization	GO:1904659; glucose transmembrane transport	2.733E-05	4.413E-03	SLC5A1, SLC5A2, SLC5A4
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	3.137E-05	4.950E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0048010; vascular endothelial growth factor receptor signaling pathway	4.196E-05	5.971E-03	AXL, KDR, PIK3CA, PIK3CB
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.250E-05	5.971E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	4.250E-05	5.971E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.250E-05	5.971E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	4.580E-05	6.311E-03	CYP19A1, CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0031328; positive regulation of cellular biosynthetic process	4.719E-05	6.422E-03	AHR, AURKB, CDK1, CDK8, ESR1, ESR2, HIF1A, IGF1R, MET, NFKB1, NOX4, NR1H4, PTGS2, TP53, TSHR
BP	GO:0032501; multicellular organismal process	GO:0010575; positive regulation of vascular endothelial growth factor production	5.142E-05	6.869E-03	CYP1B1, HIF1A, PTGS2
MF	GO:0005488; binding	GO:0008270; zinc ion binding	5.239E-05	6.956E-03	CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, NQO2, NR1H4, TP53
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	5.449E-05	7.191E-03	AXL, MET, NOX4, PIK3CA, PIK3CB
BP	GO:0008152; metabolic process	GO:0008209; androgen metabolic process	5.748E-05	7.436E-03	CYP19A1, CYP3A4, ESR1
BP	GO:0032502; developmental process	GO:0045766; positive regulation of angiogenesis	5.799E-05	7.436E-03	ALOX12, CYP1B1, HIF1A, KDR, PTGS2
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	5.936E-05	7.559E-03	ALPL, CA2, CA9, CYP1A2, ESR1, FLT3, NFKB1, PTGS2, TSHR
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	6.952E-05	8.457E-03	CDK1, CDK8, ESR1, ESR2, NR1H4
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	7.071E-05	8.507E-03	CYP1A1, CYP3A4
MF	GO:0005488; binding	GO:0042802; identical protein binding	7.249E-05	8.673E-03	ACHE, ESR1, ESR2, FLT3, IGF1R, KDR, MET, NFKB1, NQO2, PTGS2, SMN1, SMN2, TP53, TYR
MF	GO:0005488; binding	GO:0005496; steroid binding	8.424E-05	9.757E-03	CYP3A4, ESR1, ESR2, NR1H4
BP	GO:0050896; response to stimulus	GO:0071417; cellular response to organonitrogen compound	8.584E-05	9.796E-03	IGF1R, NFKB1, NOX4, NR1H4, PTGS2, TP53, TSHR
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	8.637E-05	9.796E-03	AHR, HIF1A, KDR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.776E-12	4.164E-10	CA12, CA2, CA4, CA7, CA9, CA14
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	3.339E-09	2.504E-07	HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	5.036E-08	1.511E-06	PIK3CA, KDR, PIK3CB, TP53, HIF1A, ESR1, MET, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.372E-09	4.186E-07	CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.028E-08	7.604E-07	PIK3CA, FLT3, PIK3CB, TP53, MET, HIF1A
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	7.561E-07	1.260E-05	PIK3CA, FLT3, PIK3CB, PTGS2, HIF1A, MET, TP53, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.687E-07	6.914E-06	PIK3CA, FLT3, PIM1, PIK3CB, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3.370E-07	6.914E-06	FABP4, PIK3CA, PIK3CB, PTGS2, TSHR
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	6.908E-08	1.727E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19, PTGS2
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.116E-06	1.631E-05	PIK3CA, PIK3CB, TP53, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.196E-06	1.631E-05	PIK3CA, PIK3CB, ESR1, NFKB1, ESR2
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	3.433E-06	3.961E-05	PIK3CA, PIK3CB, TP53, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	2.897E-06	3.622E-05	PIK3CA, PIK3CB, PTGS2, TP53, NFKB1
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	4.496E-06	4.817E-05	PIK3CA, PIK3CB, TP53, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.120E-05	1.050E-04	PIK3CA, PIM1, CYP1B1, PTGS2, TP53, MET, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	7.045E-06	7.045E-05	PIK3CA, PIK3CB, HIF1A, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.482E-05	1.235E-04	POLB, PIK3CA, CDK1, PIK3CB, TP53, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.367E-05	1.206E-04	PIK3CA, PIK3CB, TP53, ESR1, HIF1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	2.726E-05	1.704E-04	PIK3CA, KDR, PIK3CB, TP53, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	2.634E-05	1.704E-04	PIK3CA, KDR, PIK3CB, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	2.446E-05	1.704E-04	PIK3CA, PIK3CB, TP53, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	1.900E-05	1.500E-04	PIK3CA, KDR, PIK3CB, PTGS2
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.121E-05	1.873E-04	PIK3CA, LMNA, PIK3CB, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	2.599E-05	1.704E-04	PIK3CA, PIK3CB, TP53, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	6.182E-05	3.091E-04	FUT7, HSD17B2, CYP1A2, CYP1A1, ALPL, ALOX12, PTGS2, CYP2C19, CYP3A4, TYR, CYP19A1, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	2.599E-05	1.704E-04	PIK3CA, PIK3CB, MET, HIF1A
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	3.873E-05	2.075E-04	PIK3CA, PIK3CB, TP53, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.377E-04	6.075E-04	PIK3CA, PIM1, PIK3CB, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1.225E-04	5.743E-04	PIK3CA, CDK1, PIK3CB, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.031E-04	4.987E-04	FLT3, TP53, MET, NFKB1, IGF1R
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.471E-05	2.002E-04	CA2, NR1H4, SLC5A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.873E-05	2.075E-04	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	1.768E-04	7.167E-04	PIK3CA, CDK1, PIK3CB, TP53, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.274E-04	5.792E-04	PIK3CA, PIK3CB, ESR1, ESR2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	1.768E-04	7.167E-04	PIK3CA, KDR, PIK3CB, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	2.165E-04	8.167E-04	PIK3CA, KDR, PIK3CB, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.914E-04	7.554E-04	PIK3CA, PIK3CB, PTGS2, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	2.671E-04	9.540E-04	PIK3CA, PIK3CB, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	2.671E-04	9.540E-04	PIK3CA, PIK3CB, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	5.445E-04	1.655E-03	POLB, PIK3CA, PIK3CB, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	3.952E-04	1.347E-03	PIK3CA, PIK3CB, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	4.300E-04	1.402E-03	PIK3CA, PIK3CB, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	5.620E-04	1.655E-03	PIK3CA, PIK3CB, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.773E-03	4.585E-03	PIK3CA, PIK3CB, NFKB1, TSHR
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2.119E-03	5.386E-03	PIK3CA, ALOX12, PIK3CB
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	4.169E-04	1.390E-03	PIK3CA, PIK3CB, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	5.109E-04	1.631E-03	PIK3CA, PIK3CB, HIF1A
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	3.348E-04	1.168E-03	PIK3CA, PIK3CB, TP53
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	2.309E-03	5.677E-03	PIK3CA, PIK3CB, HIF1A
09160 Human Diseases	09167 Infectious diseases	hsa05146	Amoebiasis	2.244E-03	5.610E-03	PIK3CA, PIK3CB, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	9.068E-04	2.473E-03	PIK3CA, PIK3CB, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	3.017E-03	6.858E-03	ACHE, PIK3CA, PIK3CB
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	2.509E-03	5.974E-03	PIK3CA, PIK3CB, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	2.648E-03	6.207E-03	PIK3CA, PIK3CB, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	2.866E-03	6.614E-03	PIK3CA, PIK3CB, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	2.509E-03	5.974E-03	PIK3CA, PIK3CB, NFKB1
09150 Organismal Systems	09149 Aging	hsa04213	Longevity regulating pathway - multiple species	6.175E-04	1.781E-03	PIK3CA, PIK3CB, IGF1R
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	5.626E-04	1.655E-03	PIK3CA, PIK3CB, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05100	Bacterial invasion of epithelial cells	1.099E-03	2.944E-03	PIK3CA, PIK3CB, MET
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.095E-03	6.929E-03	ALOX12, CYP2C19, PTGS2
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	3.585E-03	7.908E-03	PIK3CA, PIK3CB, NFKB1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.530E-04	6.558E-04	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04152	AMPK signaling pathway	4.120E-03	8.956E-03	PIK3CA, PIK3CB, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.695E-04	2.138E-03	CYP1A2, CYP3A4, CYP2C19
09150 Organismal Systems	09154 Digestive system	hsa04973	Carbohydrate digestion and absorption	2.178E-04	8.167E-04	PIK3CA, PIK3CB, SLC5A1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6.462E-04	1.829E-03	CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.626E-04	1.655E-03	ALOX12, CYP2C19, PTGS2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.775E-05	2.987E-04	CYP1A2, CYP3A4, CYP2C19
09150 Organismal Systems	09155 Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4.620E-03	9.900E-03	PIK3CA, PIK3CB
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.620E-03	4.263E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1;
NA: NA	Rheumatold arthritis	NA	PTGS2;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	SLC5A4; SLC5A1; SLC5A2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; PIK3CA; KDR; FLT3; HIF1A; PIK3CB; TP53; CA9;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1;
NA: NA	Postmenopausal disorder	NA	ESR1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2;
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1;
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1;
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; TP53;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; ALPL;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1; CDK1; IGF1R; ACHE; PTGS2;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1;
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1;
C00-D49: Neoplasms	Prostate cancer	C61	ESR1; FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TP53;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; PTGS2; SLC5A4; SLC5A1; SLC5A2;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	SLC5A2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Renal cancer	C64	KDR; CA9;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2;
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1;
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1/2 diabetes	E08-E13	SLC5A4;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PTGS2; TYR;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; TP53;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
NA: NA	HIV infections	NA	AHR;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1; IGF1R;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	PIK3CA; TP53;
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1; FLT3;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PTGS2;
J00-J99: Diseases of the respiratory system	Asthma	J45	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	PIK3CB;
NA: NA	Joint and muscular pain	NA	PTGS2;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; ACHE;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Cancer	C00-C96	ESR1; PIM1; MET; CDK1; IGF1R; PIK3CA; KDR; NFKB1; FLT3; ACHE; HIF1A; PTGS2; PIK3CB; NQO2; TP53; CA9;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PTGS2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PTGS2; CYP19A1;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1;
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1; PTGS2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; PTGS2;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1; NPSR1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
NA: NA	Menopausal disorder	NA	ESR1;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL; PTGS2;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
NA: NA	Gonorrheal vaginitis	NA	ESR1;
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1;
C00-D49: Neoplasms	Breast cancer	C50	ESR1; CDK1; IGF1R; KDR; FLT3; NQO2; CYP19A1; CA9;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS2;
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET; SLC5A2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; TP53;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS2;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; PTGS2;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases