CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2B;
Hydrolase	ACHE;
Protein Kinase	MAPK1; CDK8; CSNK2A1;
Lyase	CA2; CA12; CA9; CA14; CA5B; CA7; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	AKR1B10; HSD17B1; CBR1; AKR1B1; ALOX15; AKR1C3;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	HIF1A; NFKB1;
Unclassified	LMNA; THPO; APP;
Oxidoreductase	XDH;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP19A1; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903

Showing 1 to 10 of 37 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.651E-09	3.207E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.438E-08	4.628E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0009987; cellular process	GO:0071276; cellular response to cadmium ion	3.856E-07	1.810E-04	AKR1C3, CYP1A2, MAPK1, MMP9
BP	GO:0008152; metabolic process	GO:0044597; daunorubicin metabolic process	3.907E-07	1.810E-04	AKR1B1, AKR1B10, AKR1C3
BP	GO:0008152; metabolic process	GO:0044598; doxorubicin metabolic process	3.907E-07	1.810E-04	AKR1B1, AKR1B10, AKR1C3
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	6.400E-07	2.534E-04	ACHE, AKR1B1, AKR1B10, AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	6.954E-07	2.704E-04	AKR1C3, HIF1A, MMP1, MMP2, MMP9
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	1.967E-06	6.118E-04	AKR1C3, HIF1A, MMP1, MMP2, MMP9
BP	GO:0050896; response to stimulus	GO:0034614; cellular response to reactive oxygen species	2.157E-06	6.616E-04	AKR1B1, AKR1C3, CYP1B1, MAPK1, MMP9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.129E-05	2.702E-03	CA2, CA7

Showing 1 to 10 of 26 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.784E-21	3.982E-19	CA12, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.171E-09	8.375E-08	HSD17B1, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.710E-06	1.361E-04	CBR1, ALOX15, AKR1C3, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.097E-05	2.242E-04	CBR1, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.235E-05	3.551E-04	CYP1A2, ALOX15, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.956E-05	6.551E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.503E-05	4.763E-04	CYP1A2, XDH
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.187E-03	8.487E-03	MAPK1, MMP9, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	9.817E-04	7.388E-03	MAPK1, HIF1A, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	3.750E-08	1.788E-06	HSD17B1, CYP1A1, AKR1C3, CYP1B1, CYP19A1

Showing 1 to 10 of 20 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; MMP9; MAPK1; MMP2; CA9;
C00-D49: Neoplasms	Glioma	C71	APP;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CSNK2A1; NFKB1; ACHE; HIF1A; MMP9; MAPK1; MMP2; APP; CA9;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Prostate cancer	C61	AKR1C3;

Showing 1 to 10 of 79 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cedrela salvadorensis

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities