Plant Name: Durio carinatus
Taxonomic Information:
Plant ID: NPO13813
Plant Latin Name: Durio carinatus
Taxonomy Genus: Durio
Taxonomy Family: Malvaceae
Plant External Links:
NCBI TaxonomyDB:
140961
Plant-of-the-World-Online:
559512-1
Used in Medicines:
Unknown.
Geographical Distribution:
Indonesia
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| PTPN1; | |
| NR1H4; | |
| AKR1B10; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 1.608E-07 | 1.751E-03 | GPBAR1, NR1H4 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 6.274E-05 | 2.451E-01 | NR1H4, PTPN1 |
| CC | GO:0044464; cell part | GO:0097443; sorting endosome | 1.552E-03 | 5.541E-01 | PTPN1 |
| MF | GO:0003824; catalytic activity | GO:0001758; retinal dehydrogenase activity | 1.811E-03 | 5.715E-01 | AKR1B10 |
| MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 1.811E-03 | 5.715E-01 | NR1H4 |
| MF | GO:0005488; binding | GO:0046965; retinoid X receptor binding | 3.877E-03 | 7.756E-01 | NR1H4 |
| MF | GO:0005488; binding | GO:0016922; ligand-dependent nuclear receptor binding | 5.425E-03 | 8.815E-01 | NR1H4 |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 4.149E-02 | 1.000E+00 | LMNA |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 8.969E-03 | 3.221E-02 | AKR1B10 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 7.478E-03 | 3.221E-02 | AKR1B10 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 7.975E-03 | 3.221E-02 | AKR1B10 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 1.466E-02 | 3.221E-02 | AKR1B10 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.837E-02 | 3.221E-02 | PTPN1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.763E-02 | 3.221E-02 | NR1H4 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.837E-02 | 3.221E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 2.058E-02 | 3.221E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 2.230E-02 | 3.221E-02 | LMNA |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 2.696E-02 | 3.504E-02 | PTPN1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
