CMAUP Plant Collective Molecular Activities

Plant Name: Cheilanthes marantae

Taxonomic Information:

Plant ID: NPO13798
Plant Latin Name: Cheilanthes marantae
Taxonomy Genus: Cheilanthes
Taxonomy Family: Pteridaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; HCAR2; ADORA2A; ADORA1;
Enzyme_unclassified	TK1; ADK;
Lyase	CA2; CA14; CA12; CA9;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TK1	Thymidine kinase, cytosolic	P04183	CHEMBL2883
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.930E-11	1.073E-06	CA12, CA14, CA2, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.868E-09	3.533E-05	CA12, CA14, CA2, CA9
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	3.493E-09	3.533E-05	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	8.380E-09	4.562E-05	ADORA1, ADORA2A, ADORA3
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.070E-07	1.212E-03	CA12, CA2, CA9
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	7.235E-07	1.212E-03	ADORA1, ADORA2A
BP	GO:0051179; localization	GO:0044070; regulation of anion transport	8.661E-06	9.933E-03	ADORA1, ADORA2A, CA2
CC	GO:0044456; synapse part	GO:0099055; integral component of postsynaptic membrane	8.667E-06	9.933E-03	ADORA1, ADORA2A

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	7.476E-11	1.645E-09	CA12, CA2, CA9, CA14
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.106E-04	1.217E-03	HCAR2, ADORA2A, ADORA1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.935E-04	2.152E-03	ADORA2A, ADORA3, ADORA1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.557E-03	8.562E-03	ADORA3, ADORA1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
C00-D49: Neoplasms	Cancer	C00-C96	TK1; ADORA3; CA9;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
C00-D49: Neoplasms	Solid tumours	C00-D48	TK1; CA9;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HCAR2;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A; HCAR2;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HCAR2;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HCAR2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;
NA: NA	Edema	NA	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADORA1;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HCAR2;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK;
A00-B99: Certain infectious and parasitic diseases	Adult varicella zoster virus infection	B02	TK1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Graft-versus-host disease	T86.0	TK1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TK1;
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA1; ADORA2A; ADORA3;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1; HCAR2;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Brain cancer	C71, D33	TK1;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA1; ADORA2A;
C00-D49: Neoplasms	Pancreatic cancer	C25	TK1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADORA2A; ADK;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Prostate cancer	C61	TK1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases