Plant Name: Tripterygium wilfordii
Taxonomic Information:
Plant ID: NPO13661
Plant Latin Name: Tripterygium wilfordii
Taxonomy Genus: Tripterygium
Taxonomy Family: Celastraceae
Plant External Links:
NCBI TaxonomyDB:
458696
Plant-of-the-World-Online:
162908-1
Used in Medicines:
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Antiphlogistic; Depurative
Geographical Distribution:
China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PTPN11; | |
| HKDC1; TERT; USP2; UBE2N; | |
| MAOB; | |
| MAPT; HSF1; RAB9A; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP19A1; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Enzyme_unclassified | HKDC1 | Putative hexokinase HKDC1 | Q2TB90 | CHEMBL1741200 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Enzyme_unclassified | UBE2N | Ubiquitin-conjugating enzyme E2 N | P61088 | CHEMBL6089 |
| Oxidoreductase | MAOB | Monoamine oxidase B | P27338 | CHEMBL2039 |
| Protein Phosphatase | PTPN11 | Protein-tyrosine phosphatase 2C | Q06124 | CHEMBL3864 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | HSF1 | Heat shock factor protein 1 | Q00613 | CHEMBL5869 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0045931; positive regulation of mitotic cell cycle | 9.387E-07 | 2.044E-02 | HSF1, PTPN11, TERT, USP2 |
| BP | GO:0050896; response to stimulus | GO:0046686; response to cadmium ion | 3.746E-06 | 4.079E-02 | HSF1, NPC1, TERT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00524 | Butirosin and neomycin biosynthesis | 2.747E-03 | 7.114E-02 | HKDC1 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00340 | Histidine metabolism | 1.312E-02 | 7.114E-02 | MAOB |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00360 | Phenylalanine metabolism | 9.313E-03 | 7.114E-02 | MAOB |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00350 | Tyrosine metabolism | 1.909E-02 | 7.114E-02 | MAOB |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00330 | Arginine and proline metabolism | 2.717E-02 | 7.114E-02 | MAOB |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 2.984E-02 | 7.114E-02 | HSF1 |
| 09160 Human Diseases | 09161 Cancers | hsa05211 | Renal cell carcinoma | 3.572E-02 | 7.114E-02 | PTPN11 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00010 | Glycolysis / Gluconeogenesis | 3.625E-02 | 7.114E-02 | HKDC1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 3.731E-02 | 7.114E-02 | MAOB |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 3.784E-02 | 7.114E-02 | PTPN11 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | TERT; |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT; |
| C00-D49: Neoplasms | Breast cancer | C50 | TERT; |
| C00-D49: Neoplasms | Melanoma | C43 | TERT; |
| C00-D49: Neoplasms | Tumors | C00-D48 | TERT; |
| C00-D49: Neoplasms | Prostate cancer | C61 | TERT; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TERT; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TERT; |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TERT; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TERT; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
