Plant Name: Rabdosia longituba
Taxonomic Information:
Plant ID: NPO13628
Plant Latin Name: Rabdosia longituba
Taxonomy Genus: Isodon
Taxonomy Family: Lamiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| HSP90AA1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Unclassified | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | CHEMBL3880 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0042026; protein refolding | 7.766E-04 | 1.000E+00 | HSP90AA1 |
| BP | GO:0009987; cellular process | GO:0038128; ERBB2 signaling pathway | 2.019E-03 | 1.000E+00 | HSP90AA1 |
| BP | GO:0008152; metabolic process | GO:0045429; positive regulation of nitric oxide biosynthetic process | 2.123E-03 | 1.000E+00 | HSP90AA1 |
| BP | GO:0008152; metabolic process | GO:0050999; regulation of nitric-oxide synthase activity | 2.278E-03 | 1.000E+00 | HSP90AA1 |
| BP | GO:0050896; response to stimulus | GO:0046677; response to antibiotic | 2.381E-03 | 1.000E+00 | HSP90AA1 |
| BP | GO:0009987; cellular process | GO:0048010; vascular endothelial growth factor receptor signaling pathway | 3.727E-03 | 1.000E+00 | HSP90AA1 |
| BP | GO:0009987; cellular process | GO:1900034; regulation of cellular response to heat | 4.038E-03 | 1.000E+00 | HSP90AA1 |
| BP | GO:0050896; response to stimulus | GO:0009408; response to heat | 4.556E-03 | 1.000E+00 | HSP90AA1 |
| BP | GO:0009987; cellular process | GO:0038096; Fc-gamma receptor signaling pathway involved in phagocytosis | 6.730E-03 | 1.000E+00 | HSP90AA1 |
| BP | GO:0008152; metabolic process | GO:0018108; peptidyl-tyrosine phosphorylation | 9.629E-03 | 1.000E+00 | HSP90AA1 |
| BP | GO:0009987; cellular process | GO:0010389; regulation of G2/M transition of mitotic cell cycle | 1.025E-02 | 1.000E+00 | HSP90AA1 |
| BP | GO:0009987; cellular process | GO:0043254; regulation of protein complex assembly | 2.040E-02 | 1.000E+00 | HSP90AA1 |
| BP | GO:0050896; response to stimulus | GO:0009636; response to toxic substance | 2.081E-02 | 1.000E+00 | HSP90AA1 |
| BP | GO:0002376; immune system process | GO:0043312; neutrophil degranulation | 2.495E-02 | 1.000E+00 | HSP90AA1 |
| CC | GO:0043226; organelle | GO:0042470; melanosome | 5.229E-03 | 1.000E+00 | HSP90AA1 |
| CC | GO:0044464; cell part | GO:0043209; myelin sheath | 7.610E-03 | 1.000E+00 | HSP90AA1 |
| CC | GO:0044464; cell part | GO:0034774; secretory granule lumen | 1.662E-02 | 1.000E+00 | HSP90AA1 |
| MF | GO:0098772; molecular function regulator | GO:0030235; nitric-oxide synthase regulator activity | 3.624E-04 | 1.000E+00 | HSP90AA1 |
| MF | GO:0005488; binding | GO:1990782; protein tyrosine kinase binding | 3.520E-03 | 1.000E+00 | HSP90AA1 |
| MF | GO:0005488; binding | GO:0042826; histone deacetylase binding | 5.591E-03 | 1.000E+00 | HSP90AA1 |
| MF | GO:0003824; catalytic activity | GO:0004713; protein tyrosine kinase activity | 9.370E-03 | 1.000E+00 | HSP90AA1 |
| MF | GO:0005488; binding | GO:0042803; protein homodimerization activity | 4.116E-02 | 1.000E+00 | HSP90AA1 |
| MF | Unclassified; | GO:0032403; protein complex binding | 4.116E-02 | 1.000E+00 | HSP90AA1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 2.850E-03 | 7.920E-03 | HSP90AA1 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 4.450E-03 | 7.920E-03 | HSP90AA1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04914 | Progesterone-mediated oocyte maturation | 4.900E-03 | 7.920E-03 | HSP90AA1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04612 | Antigen processing and presentation | 3.850E-03 | 7.920E-03 | HSP90AA1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 4.950E-03 | 7.920E-03 | HSP90AA1 |
| 09120 Genetic Information Processing | 09123 Folding, sorting and degradation | hsa04141 | Protein processing in endoplasmic reticulum | 8.450E-03 | 1.127E-02 | HSP90AA1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 1.705E-02 | 1.949E-02 | HSP90AA1 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.985E-02 | 1.985E-02 | HSP90AA1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Melanoma | C43 | HSP90AA1; |
| C00-D49: Neoplasms | Breast cancer | C50 | HSP90AA1; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | HSP90AA1; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | HSP90AA1; |
| C00-D49: Neoplasms | Refractory hematological malignancies | NA | HSP90AA1; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | HSP90AA1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | HSP90AA1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
