CMAUP Plant Collective Molecular Activities

Plant Name: Swertia paniculata

Taxonomic Information:

Plant ID: NPO1362
Plant Latin Name: Swertia paniculata
Taxonomy Genus: Swertia
Taxonomy Family: Gentianaceae

Plant External Links:

NCBI TaxonomyDB: 559637
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Ayurveda

Geographical Distribution:

India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA12; CA7;
Nuclear hormone receptor subfamily 3 group C	NR3C1;
Oxidoreductase	TYR;
Enzyme_unclassified	HSD17B2;
Transcription Factor	AHR; HIF1A;
Unclassified	RAB9A; PAX8; LMNA; NPC1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP3A4; CYP1A1; CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group C	NR3C1	Glucocorticoid receptor	P04150	CHEMBL2034
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.597E-09	6.602E-05	CYP1A1, CYP1A2, CYP1B1, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.769E-08	2.106E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.982E-08	2.106E-04	CYP1A1, CYP1A2, CYP1B1, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.457E-07	1.624E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	9.919E-07	1.661E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	2.186E-06	2.644E-03	CYP1A1, CYP3A4
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	2.764E-06	3.168E-03	AHR, HIF1A, NR3C1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.370E-06	3.660E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0020037; heme binding	4.095E-06	3.660E-03	CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.370E-06	3.660E-03	CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	7.279E-06	5.661E-03	CYP1A1, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	9.921E-06	7.449E-03	CYP1A1, CYP1A2, CYP1B1, CYP3A4
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.091E-05	7.666E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.091E-05	7.666E-03	CYP1A2, CYP3A4
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	1.254E-05	8.535E-03	AHR, CYP1A1, CYP1A2, CYP1B1, HIF1A, HSD17B2, LMNA, PAX8, SMN1, SMN2, TYR
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.527E-05	9.236E-03	CYP1A2, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.036E-09	3.626E-08	CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.750E-07	6.562E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.997E-07	6.997E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.943E-06	4.325E-05	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	9.754E-06	6.828E-05	HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.157E-05	1.258E-04	CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.724E-04	1.192E-03	CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.543E-03	6.000E-03	CYP1A2, CYP3A4
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	9.179E-05	4.590E-04	CA12, CA7

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	NR3C1; TYR;
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	NR3C1;
H60-H95: Diseases of the ear and mastoid process	Otitis externa	H60	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Xerophthalmia	E50.6-E50.7	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Duchenne muscular dystrophy	G71.0	NR3C1;
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	NR3C1;
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Cushing's disease	E24.0	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
NA: NA	HIV infections	NA	AHR;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	NR3C1;
C00-D49: Neoplasms	Multiple myeloma	C90	AHR;
NA: NA	Corticosteroid-responsive inflammation	NA	NR3C1;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	NR3C1;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Melanoma	C43	TYR;
J00-J99: Diseases of the respiratory system	Asthma	J45	NR3C1;
G00-G99: Diseases of the nervous system G00-G99	Ataxia telangiectasia	G11.3	NR3C1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	NR3C1;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NR3C1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Spinal cord injury	S14, S24, S34	NR3C1;
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A;
NA: NA	Non-infectious rhinitis	NA	NR3C1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	NR3C1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	NR3C1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Skin allergies	T78.4	NR3C1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	NR3C1;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
L00-L99: Diseases of the skin and subcutaneous tissue	Eczema	L20-L30	NR3C1;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases