CMAUP Plant Collective Molecular Activities

Plant Name: Gynura segetum

Taxonomic Information:

Plant ID: NPO13501
Plant Latin Name: Gynura segetum
Taxonomy Genus: Gynura
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 210888
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Indonesia; China

Traditional Medicine System:

TCM

Medicinal Functions:

Anticoagulant; Depurative; Febrifuge; Styptic

Geographical Distribution:

Indonesia; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	TDP1; HKDC1; USP2;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Aspartic protease	CTSD;
Toll-like and Il-1 receptors	TLR2;
Unclassified	MAPT; FABP2; FABP4; FABP3; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	CTSD	Cathepsin D	P07339	CHEMBL2581
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HKDC1	Putative hexokinase HKDC1	Q2TB90	CHEMBL1741200
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.548E-09	1.123E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0051179; localization	GO:0015908; fatty acid transport	1.113E-05	1.425E-02	FABP3, PPARA, PPARD
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	2.292E-05	2.376E-02	PPARA, PPARD
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	2.292E-05	2.376E-02	FABP3, PPARD
BP	GO:0050896; response to stimulus	GO:0043434; response to peptide hormone	2.710E-05	2.682E-02	FABP3, PPARA, TLR2, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.273E-12	1.114E-10	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5.889E-04	1.443E-02	FABP4, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	7.149E-03	7.006E-02	PPARA, TSHR
09160 Human Diseases	09167 Infectious diseases	hsa05152	Tuberculosis	5.760E-03	7.006E-02	CTSD, TLR2
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	3.392E-02	1.034E-01	TSHR
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00524	Butirosin and neomycin biosynthesis	3.246E-03	5.302E-02	HKDC1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4.270E-02	1.034E-01	HKDC1
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	4.457E-02	1.034E-01	PPARA
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	4.519E-02	1.034E-01	TSHR
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	4.644E-02	1.034E-01	TLR2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases