CMAUP Plant Collective Molecular Activities

Plant Name: Cucumis melo

Taxonomic Information:

Plant ID: NPO13450
Plant Latin Name: Cucumis melo
Taxonomy Genus: Cucumis
Taxonomy Family: Cucurbitaceae

Plant External Links:

NCBI TaxonomyDB: 3656
Plant-of-the-World-Online: 292238-1

Used in Medicines:

Country/Region:

Philippines; India; Jordan; Thailand; South Korea; Argentina

Traditional Medicine System:

Medicinal Functions:

Antitussive; Digestive; Diuretic; Emetic; Expectorant; Febrifuge; Stomachic; Vermifuge

Geographical Distribution:

Afghanistan; Bangladesh; Mauritania; Sudan; Guinea; Mali; Bahamas; Ethiopia; Somalia; Argentina; Bolivia; Cameroon; Cote d'Ivoire; Benin; Ghana; Russia; Australia; Iran; Algeria; Cuba; Thailand; Venezuela; Cape Verde; Papua New Guinea; Burkina Faso; United States; Trinidad and Tobago; Zimbabwe; China; Jordan; Dominican Republic; Belize; Tanzania; Spain; Nigeria; Eritrea; Maldives; Uganda; Libya; Pakistan; Gambia; Philippines; New Caledonia; Portugal; Morocco; Saudi Arabia; South Korea; Guinea-Bissau; Kenya; Senegal; Malawi; Yemen; Nepal; Haiti; Jamaica; Albania; Angola; Myanmar; Chad; Mexico; Egypt; Nicaragua; South Africa; India; Tunisia; Austria; Mozambique; Colombia; Sri Lanka; Japan; Niger; Fiji; Zambia; Seychelles

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Transcription Factor	STAT3;
Unclassified	NPC1; ITGAL; RAB9A; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Transcription Factor	STAT3	Signal transducer and activator of transcription 3	P40763	CHEMBL4026
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	ITGAL	Leukocyte adhesion glycoprotein LFA-1 alpha	P20701	CHEMBL1803
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
CC	GO:0016020; membrane	GO:0031090; organelle membrane	5.479E-05	1.988E-01	ITGAL, LMNA, NPC1, RAB9A, STAT3
BP	GO:0051179; localization	GO:0045184; establishment of protein localization	1.048E-04	3.261E-01	LMNA, NPC1, RAB9A, STAT3
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	6.960E-04	6.985E-01	LMNA, NPC1
CC	GO:0044464; cell part	GO:0005764; lysosome	1.949E-03	8.596E-01	NPC1, RAB9A
MF	Unclassified;	GO:0004871; signal transducer activity	6.092E-03	1.000E+00	ITGAL, NPC1, STAT3

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	4.529E-04	1.630E-02	STAT3, RAB9A
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	9.949E-04	1.791E-02	STAT3, ITGAL
09160 Human Diseases	09167 Infectious diseases	hsa05144	Malaria	1.219E-02	4.797E-02	ITGAL
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.417E-02	4.797E-02	STAT3
09160 Human Diseases	09167 Infectious diseases	hsa05150	Staphylococcus aureus infection	1.392E-02	4.797E-02	ITGAL
09160 Human Diseases	09165 Cardiovascular diseases	hsa05416	Viral myocarditis	1.466E-02	4.797E-02	ITGAL
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.639E-02	4.797E-02	STAT3
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.787E-02	4.797E-02	STAT3
09150 Organismal Systems	09151 Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3.330E-02	4.797E-02	ITGAL
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	3.597E-02	4.797E-02	STAT3

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ITGAL;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	ITGAL;
H00-H59: Diseases of the eye and adnexa	Dry eye disease	H16.229	ITGAL;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Renal transplantation	D89.8	ITGAL;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ITGAL;
C00-D49: Neoplasms	Allergic conjunctivitis	C91.0, H10, H10.45, T78.4	ITGAL;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases