CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; CNR2;
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	ALPL; ALOX12; HSD17B10; NOX4; POLB;
Hydrolase	ACHE;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Transcription Factor	TP53; NFKB1;
Unclassified	FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717

Showing 1 to 10 of 22 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	1.886E-07	1.956E-04	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, NFKB1, PIM1, TP53
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	5.069E-07	3.942E-04	ALPL, AXL, CNR1, CNR2, CYP1A2, NFKB1
BP	GO:0050896; response to stimulus	GO:0010243; response to organonitrogen compound	1.105E-06	6.686E-04	CDK1, CNR1, CNR2, FLT3, IGF1R, NFKB1, NOX4, TP53
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.809E-06	9.754E-04	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	2.339E-06	1.061E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0009987; cellular process	GO:1902533; positive regulation of intracellular signal transduction	7.160E-06	2.598E-03	AXL, CDK1, CYP1B1, FLT3, KDR, MET, NOX4, TP53
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	7.420E-06	2.649E-03	CNR1, CNR2
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	7.585E-06	2.664E-03	ALOX12, IGF1R, KDR, MET, NOX4, TP53
BP	GO:0050896; response to stimulus	GO:0045471; response to ethanol	8.308E-06	2.827E-03	CDK1, CNR1, POLB, TP53
BP	GO:0009987; cellular process	GO:0051262; protein tetramerization	2.117E-05	5.835E-03	ACHE, HSD17B10, IGF1R, TP53

Showing 1 to 10 of 19 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	8.784E-04	6.965E-03	CYP1A2, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	2.902E-05	8.367E-04	KDR, TP53, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	7.587E-05	8.422E-04	CNR1, KDR, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.007E-04	1.016E-03	KDR, MET, NFKB1, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	1.357E-03	8.451E-03	KDR, MET, IGF1R
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.451E-04	1.239E-03	TP53, NFKB1, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.370E-03	8.451E-03	CYP1B1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.299E-06	1.442E-04	FLT3, TP53, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.495E-05	8.295E-04	PIM1, CYP1B1, TP53, MET, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.252E-05	8.367E-04	FLT3, PIM1, NFKB1

Showing 1 to 10 of 18 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	CNR1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; CNR1;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;

Showing 1 to 10 of 118 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Centaurea calcitrapa

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities