CMAUP Plant Collective Molecular Activities

Plant Name: Campanula medium

Taxonomic Information:

Plant ID: NPO13417
Plant Latin Name: Campanula medium
Taxonomy Genus: Campanula
Taxonomy Family: Campanulaceae

Plant External Links:

NCBI TaxonomyDB: 56154
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1;
Nicotinic acetylcholine receptor	CHRNA7;
Nuclear hormone receptor subfamily 1 group C	PPARD; PPARA; PPARG;
Enzyme_unclassified	ALOX15; HSD17B10; ALDH1A1; USP2;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	SERPINA6; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Nicotinic acetylcholine receptor	CHRNA7	Neuronal acetylcholine receptor protein alpha-7 subunit	P36544	CHEMBL2492
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Unclassified	SERPINA6	Corticosteroid binding globulin	P08185	CHEMBL2421
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	4.177E-06	1.105E-02	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0006629; lipid metabolic process	4.569E-06	1.105E-02	ALDH1A1, ALOX15, HSD17B10, PPARA, PPARD, PPARG, SERPINA6
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	4.310E-06	1.105E-02	PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	6.262E-06	1.136E-02	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	6.262E-06	1.136E-02	PPARA, PPARG
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	7.575E-06	1.269E-02	PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0015908; fatty acid transport	1.113E-05	1.731E-02	PPARA, PPARD, PPARG
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	2.292E-05	2.399E-02	PPARD, PPARG
MF	GO:0005488; binding	GO:0008289; lipid binding	5.306E-05	3.328E-02	ALOX15, PPARA, PPARD, PPARG, SERPINA6
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	6.359E-05	3.644E-02	SLCO1B1, SLCO1B3

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.097E-05	3.838E-04	PPARG, PPARA, PPARD
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	9.450E-04	1.654E-02	SLCO1B1, SLCO1B3
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	2.207E-03	2.575E-02	PTPN1, PPARA
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.653E-02	1.084E-01	PPARG, PPARD
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	2.570E-02	1.084E-01	CHRNA7
09100 Metabolism	09105 Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3.076E-02	1.084E-01	HSD17B10
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.643E-02	1.084E-01	PPARD
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.251E-02	1.084E-01	ALOX15, ALDH1A1, HSD17B10
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.957E-02	1.084E-01	ALOX15
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.145E-02	1.084E-01	ALDH1A1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases