CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; CDC25B; PTPRF;
Enzyme_unclassified	ALPL; PLA2G1B; RECQL; HSD17B10; HSD11B1; AKR1B10; POLB;
Hydrolase	GAA;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	NFKB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047

Showing 1 to 10 of 17 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	1.882E-08	1.588E-04	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	2.186E-06	4.760E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	4.370E-06	8.650E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	1.017E-05	1.846E-02	NR1H4, PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:1903897; regulation of PERK-mediated unfolded protein response	3.267E-05	3.952E-02	PTPN1, PTPN2
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	2.186E-06	4.760E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	2.035E-05	2.954E-02	ACP1, PTPN2
MF	GO:0005488; binding	GO:0032052; bile acid binding	2.615E-05	3.355E-02	NR1H4, PLA2G1B

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.917E-04	7.830E-03	AKR1B10, GAA
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	3.185E-05	2.612E-03	PTPN1, ACP1, PTPRF
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	6.091E-03	8.324E-02	PTPN1, PTPRF
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	6.029E-02	1.206E-01	NFKB1
09150 Organismal Systems	09151 Immune system	hsa04623	Cytosolic DNA-sensing pathway	5.305E-02	1.206E-01	NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	5.789E-02	1.206E-01	NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.013E-04	4.153E-03	PTPN1, NFKB1, PTPRF
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	1.371E-03	2.248E-02	RORC, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	5.386E-02	1.206E-01	NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.819E-04	7.830E-03	HSD11B1, AKR1B10, PLA2G1B, GAA, ALPL, HSD17B10

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; CDC25B;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;

Showing 1 to 5 of 5 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Palafoxia rosea

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities