Plant Name: Bryopsis pennata
Taxonomic Information:
Plant ID: NPO13341
Plant Latin Name: Bryopsis pennata
Taxonomy Genus: Bryopsis
Taxonomy Family: Bryopsidaceae
Plant External Links:
NCBI TaxonomyDB:
381411
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| MC4R; | |
| ACHE; | |
| TDP1; HKDC1; UBE2N; | |
| CA2; CA1; CA12; CA9; CA13; CA7; CA3; CA14; CA5B; CA5A; CA4; CA6; | |
| ESR2; | |
| MMP9; MMP2; | |
| TP53; NFKB1; | |
| SLC22A2; SLC22A3; SLC22A1; SLC47A2; SLC47A1; | |
| PAX8; HTT; LMNA; RAB9A; NPC1; RAD52; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | HKDC1 | Putative hexokinase HKDC1 | Q2TB90 | CHEMBL1741200 |
| Enzyme_unclassified | UBE2N | Ubiquitin-conjugating enzyme E2 N | P61088 | CHEMBL6089 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA13 | Carbonic anhydrase XIII | Q8N1Q1 | CHEMBL3912 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Peptide receptor (family A GPCR) | MC4R | Melanocortin receptor 4 | P32245 | CHEMBL259 |
| SLC superfamily of solute carriers | SLC22A2 | Solute carrier family 22 member 2 | O15244 | CHEMBL1743122 |
| SLC superfamily of solute carriers | SLC22A3 | Solute carrier family 22 member 3 | O75751 | CHEMBL2073673 |
| SLC superfamily of solute carriers | SLC22A1 | Solute carrier family 22 member 1 | O15245 | CHEMBL5685 |
| SLC superfamily of solute carriers | SLC47A2 | Multidrug and toxin extrusion protein 2 | Q86VL8 | CHEMBL1743127 |
| SLC superfamily of solute carriers | SLC47A1 | Multidrug and toxin extrusion protein 1 | Q96FL8 | CHEMBL1743126 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | PAX8 | Paired box protein Pax-8 | Q06710 | CHEMBL2362980 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | RAD52 | DNA repair protein RAD52 homolog | P43351 | CHEMBL2362978 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 7.994E-12 | 1.582E-08 | CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2, MMP2, MMP9, TP53 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.289E-07 | 1.559E-04 | CYP2C19, CYP2C9, CYP2D6 |
| MF | GO:0005215; transporter activity | GO:0005329; dopamine transmembrane transporter activity | 1.289E-07 | 1.559E-04 | SLC22A1, SLC22A2, SLC22A3 |
| BP | GO:0051179; localization | GO:0006855; drug transmembrane transport | 1.368E-07 | 1.568E-04 | SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 5.070E-07 | 5.105E-04 | CYP2A6, CYP2C19, CYP2C9, CYP2D6 |
| MF | GO:0005215; transporter activity | GO:0015651; quaternary ammonium group transmembrane transporter activity | 5.392E-07 | 5.105E-04 | SLC22A1, SLC22A2, SLC22A3 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.496E-31 | 3.258E-27 | CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015872; dopamine transport | 1.407E-06 | 1.094E-03 | SLC22A1, SLC22A2, SLC22A3 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.407E-06 | 1.094E-03 | CYP2A6, CYP2C19, CYP2C9 |
| BP | GO:0051179; localization | GO:0015697; quaternary ammonium group transport | 1.407E-06 | 1.094E-03 | SLC22A1, SLC22A2, SLC22A3 |
| MF | GO:0003824; catalytic activity | GO:0008392; arachidonic acid epoxygenase activity | 4.319E-06 | 2.766E-03 | CYP2A6, CYP2C19, CYP2C9 |
| BP | GO:0051179; localization | GO:0072488; ammonium transmembrane transport | 5.176E-06 | 3.220E-03 | SLC22A1, SLC22A2, SLC22A3 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 8.403E-06 | 4.945E-03 | CYP2A6, CYP2C19, CYP2C9 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 1.070E-05 | 5.417E-03 | CA2, CA7 |
| MF | GO:0005215; transporter activity | GO:0015307; drug:proton antiporter activity | 1.070E-05 | 5.417E-03 | SLC47A1, SLC47A2 |
| MF | GO:0005215; transporter activity | GO:0005333; norepinephrine transmembrane transporter activity | 1.070E-05 | 5.417E-03 | SLC22A1, SLC22A2 |
| MF | GO:0005215; transporter activity | GO:0005277; acetylcholine transmembrane transporter activity | 1.070E-05 | 5.417E-03 | SLC22A1, SLC22A2 |
| MF | GO:0005215; transporter activity | GO:0008513; secondary active organic cation transmembrane transporter activity | 1.070E-05 | 5.417E-03 | SLC22A1, SLC22A2 |
| BP | GO:0051179; localization | GO:0015874; norepinephrine transport | 2.137E-05 | 9.694E-03 | SLC22A1, SLC22A2 |
| BP | GO:0051179; localization | GO:1901374; acetate ester transport | 2.137E-05 | 9.694E-03 | SLC22A1, SLC22A2 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 6.699E-24 | 7.294E-20 | CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.428E-22 | 7.771E-19 | CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 1.337E-30 | 1.444E-28 | CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14, CA13 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 7.862E-06 | 4.246E-04 | CYP2C9, CYP2A6, CYP2D6, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 5.919E-05 | 2.131E-03 | MMP2, MMP9, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 7.764E-04 | 9.260E-03 | PAX8, MMP2, TP53, MMP9, NFKB1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 3.316E-04 | 7.177E-03 | CYP2C9, CYP2A6, CYP2D6 |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 3.323E-04 | 7.177E-03 | PAX8, TP53, MMP9, NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 8.090E-04 | 9.260E-03 | MMP2, MMP9, ESR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05231 | Choline metabolism in cancer | 8.574E-04 | 9.260E-03 | SLC22A3, SLC22A2, SLC22A1 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 4.668E-04 | 8.402E-03 | CYP2C9, CYP2A6, CYP2C19 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 8.221E-04 | 9.260E-03 | CA2, CA4 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2; |
| NA: NA | Edema | NA | CA2; |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2; |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
