CMAUP Plant Collective Molecular Activities

Plant Name: Tacca chantrieri

Taxonomic Information:

Plant ID: NPO13332
Plant Latin Name: Tacca chantrieri
Taxonomy Genus: Tacca
Taxonomy Family: Taccaceae

Plant External Links:

NCBI TaxonomyDB: 85283
Plant-of-the-World-Online: 827891-1

Used in Medicines:

Country/Region:

Thailand; China

Traditional Medicine System:

TCM

Geographical Distribution:

Bangladesh; Myanmar; India; Cambodia; Vietnam; China; Laos; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1; TSHR;
Enzyme_unclassified	TDP1; PTGES; BRCA1;
Oxidoreductase	MAOA;
Toll-like and Il-1 receptors	TLR9;
Transcription Factor	HIF1A;
Unclassified	APP; HTT; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PTGES	Prostaglandin E synthase	O14684	CHEMBL5658
Enzyme_unclassified	BRCA1	Breast cancer type 1 susceptibility protein	P38398	CHEMBL5990
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Toll-like and Il-1 receptors	TLR9	Toll-like receptor 9	Q9NR96	CHEMBL5804
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0032640; tumor necrosis factor production	1.768E-06	6.983E-03	APP, TLR9
BP	GO:0009987; cellular process	GO:0008088; axo-dendritic transport	1.924E-06	6.983E-03	APP, HIF1A, MAPT
BP	GO:0051179; localization	GO:0060341; regulation of cellular localization	3.447E-06	1.072E-02	APP, HIF1A, HTT, MAPT, NPSR1, TLR9
BP	GO:0009987; cellular process	GO:1990000; amyloid fibril formation	8.240E-06	1.468E-02	APP, MAPT
CC	GO:0044464; cell part	GO:0005641; nuclear envelope lumen	8.240E-06	1.468E-02	APP, PTGES
BP	GO:0032501; multicellular organismal process	GO:0048143; astrocyte activation	1.059E-05	1.537E-02	APP, MAPT
MF	GO:0005488; binding	GO:0034452; dynactin binding	1.617E-05	1.806E-02	HTT, MAPT
MF	GO:0005488; binding	GO:0031072; heat shock protein binding	2.495E-05	2.587E-02	HIF1A, HTT, MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.654E-03	6.781E-02	APP, MAOA
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	3.670E-03	7.492E-02	APP, MAPT
09100 Metabolism	09105 Amino acid metabolism	hsa00360	Phenylalanine metabolism	9.313E-03	7.492E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00350	Tyrosine metabolism	1.909E-02	7.492E-02	MAOA
09160 Human Diseases	09167 Infectious diseases	hsa05143	African trypanosomiasis	1.909E-02	7.492E-02	TLR9
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.179E-02	7.492E-02	MAOA
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	3.572E-02	7.492E-02	HIF1A
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.625E-02	7.492E-02	HIF1A
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.731E-02	7.492E-02	MAOA
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	3.837E-02	7.492E-02	TSHR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOA; PTGES;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases