Plant Name: Uncaria quadrangularis
Taxonomic Information:
Plant ID: NPO13323
Plant Latin Name: Uncaria quadrangularis
Taxonomy Genus: Uncaria
Taxonomy Family: Rubiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0050968; detection of chemical stimulus involved in sensory perception of pain | 3.106E-04 | 1.000E+00 | TRPA1 |
| BP | GO:0032501; multicellular organismal process | GO:0050955; thermoception | 3.106E-04 | 1.000E+00 | TRPA1 |
| BP | GO:0032501; multicellular organismal process | GO:0050966; detection of mechanical stimulus involved in sensory perception of pain | 1.035E-03 | 1.000E+00 | TRPA1 |
| BP | GO:0032501; multicellular organismal process | GO:0055015; ventricular cardiac muscle cell development | 1.035E-03 | 1.000E+00 | LMNA |
| BP | GO:0032501; multicellular organismal process | GO:0048265; response to pain | 1.656E-03 | 1.000E+00 | TRPA1 |
| BP | GO:0009987; cellular process | GO:0090201; negative regulation of release of cytochrome c from mitochondria | 1.759E-03 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0007077; mitotic nuclear envelope disassembly | 4.551E-03 | 1.000E+00 | LMNA |
| BP | GO:0051179; localization | GO:0051209; release of sequestered calcium ion into cytosol | 4.654E-03 | 1.000E+00 | TRPA1 |
| BP | GO:0009987; cellular process | GO:0051289; protein homotetramerization | 7.648E-03 | 1.000E+00 | TRPA1 |
| BP | GO:0009987; cellular process | GO:2001237; negative regulation of extrinsic apoptotic signaling pathway | 1.064E-02 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 1.074E-02 | 1.000E+00 | LMNA |
| BP | GO:0050896; response to stimulus | GO:0042542; response to hydrogen peroxide | 1.115E-02 | 1.000E+00 | TRPA1 |
| BP | Unclassified; | GO:2000021; regulation of ion homeostasis | 2.142E-02 | 1.000E+00 | TRPA1 |
| BP | GO:0051179; localization | GO:1900180; regulation of protein localization to nucleus | 2.275E-02 | 1.000E+00 | LMNA |
| BP | GO:0051179; localization | GO:0006810; transport | 4.461E-02 | 1.000E+00 | LMNA, TRPA1 |
| CC | GO:0044464; cell part | GO:0032421; stereocilium bundle | 5.177E-04 | 1.000E+00 | TRPA1 |
| CC | GO:0043226; organelle | GO:0016607; nuclear speck | 3.784E-02 | 1.000E+00 | LMNA |
| MF | GO:0005215; transporter activity | GO:0015278; calcium-release channel activity | 1.863E-03 | 1.000E+00 | TRPA1 |
| MF | GO:0005215; transporter activity | GO:0008381; mechanosensitive ion channel activity | 3.418E-02 | 1.000E+00 | TRPA1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 7.386E-03 | 1.222E-02 | LMNA |
| 09150 Organismal Systems | 09157 Sensory system | hsa04750 | Inflammatory mediator regulation of TRP channels | 9.776E-03 | 1.222E-02 | TRPA1 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 8.283E-03 | 1.222E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 8.980E-03 | 1.222E-02 | LMNA |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.395E-02 | 1.395E-02 | LMNA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
