CMAUP Plant Collective Molecular Activities

Plant Name: Viguiera cordifolia

Plant ID: NPO13321
Plant Latin Name: Viguiera cordifolia
Taxonomy Genus: Viguiera
Taxonomy Family: Asteraceae

NCBI TaxonomyDB: 684029
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALOX12; ALOX15; AKR1B1; HPGD;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	4.658E-09	5.072E-05	ALOX12, ALOX15, HPGD
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	5.361E-08	1.945E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	5.361E-08	1.945E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	1.608E-07	4.377E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	1.608E-07	4.377E-04	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	5.359E-07	1.167E-03	ALOX12, ALOX15
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.723E-02	1.000E+00	AKR1B1
CC	GO:0044464; cell part	GO:0031234; extrinsic component of cytoplasmic side of plasma membrane	1.850E-02	1.000E+00	ALOX15

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.399E-05	9.399E-04	ALOX15, ALOX12
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.074E-04	1.537E-03	ALOX15, ALOX12
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.158E-03	7.192E-03	ALOX15, AKR1B1, ALOX12
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	7.230E-03	1.281E-02	ALOX15
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	8.969E-03	1.281E-02	AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	1.466E-02	1.833E-02	AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	7.478E-03	1.281E-02	AKR1B1
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2.426E-02	2.696E-02	ALOX12
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7.975E-03	1.281E-02	AKR1B1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	4.420E-02	4.420E-02	HPGD

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases