Plant Name: Garcinia hanburyi
Taxonomic Information:
Plant ID: NPO13310
Plant Latin Name: Garcinia hanburyi
Taxonomy Genus: Garcinia
Taxonomy Family: Clusiaceae
Plant External Links:
NCBI TaxonomyDB:
231906
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Thailand; China; IndiaTraditional Medicine System:
TCM; AyurvedaGeographical Distribution:
India; China; Thailand
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| IKBKB; | |
| NR1H4; | |
| AKR1B10; | |
| TP53; | |
| MCL1; TXN2; TXN; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Kinase | IKBKB | Inhibitor of nuclear factor kappa B kinase beta subunit | O14920 | CHEMBL1991 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
| Unclassified | TXN2 | Thioredoxin, mitochondrial | Q99757 | CHEMBL2189153 |
| Unclassified | TXN | Thioredoxin | P10599 | CHEMBL2010624 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 5.788E-07 | 6.302E-03 | GPBAR1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0006662; glycerol ether metabolic process | 1.059E-05 | 3.814E-02 | TXN, TXN2 |
| BP | GO:0009987; cellular process | GO:0019725; cellular homeostasis | 1.226E-05 | 3.814E-02 | MCL1, NR1H4, TP53, TXN, TXN2 |
| BP | GO:0009987; cellular process | GO:0060548; negative regulation of cell death | 3.102E-05 | 6.755E-02 | IKBKB, MCL1, NR1H4, TP53, TXN |
| CC | GO:0032991; macromolecular complex | GO:0097136; Bcl-2 family protein complex | 2.793E-03 | 5.430E-01 | MCL1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.734E-05 | 1.832E-03 | IKBKB, TP53, MCL1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 3.824E-04 | 6.235E-03 | IKBKB, TP53, MCL1 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 2.548E-04 | 6.235E-03 | IKBKB, TP53, MCL1 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 3.804E-04 | 6.235E-03 | IKBKB, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 4.653E-04 | 6.235E-03 | IKBKB, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 6.907E-04 | 6.611E-03 | IKBKB, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 6.452E-04 | 6.611E-03 | IKBKB, TP53 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 1.250E-03 | 1.047E-02 | IKBKB, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 1.842E-03 | 1.234E-02 | IKBKB, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 1.533E-03 | 1.141E-02 | IKBKB, TP53 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | MCL1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
