CMAUP Plant Collective Molecular Activities

Plant Name: Illicium verum

Taxonomic Information:

Plant ID: NPO13274
Plant Latin Name: Illicium verum
Taxonomy Genus: Illicium
Taxonomy Family: Schisandraceae

Plant External Links:

NCBI TaxonomyDB: 124778
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Thailand; Jordan; India; Vietnam; China

Traditional Medicine System:

TCM; Ayurveda; Siddha

Medicinal Functions:

Antibacterial; Appetizer; Carminative; Expectorant; Homeopathy; Stimulant

Geographical Distribution:

India; Jordan; China; Vietnam; Thailand

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; CNR2;
Peptide receptor (family A GPCR)	TSHR;
Hydrolase	GAA;
Enzyme_unclassified	GLA; BLM; HPGD; HSD17B10; ALDH1A1;
Protein Kinase	MAPK1;
Lyase	CA2; CA1; CA12; CA9; CA5B; CA3; CA14; CA7; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Nuclear hormone receptor subfamily 2 group B	RXRA;
Oxidoreductase	ALOX5;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	HIF1A; TP53; NFKB1;
SLC superfamily of solute carriers	SLC6A2; SLC6A3;
Unclassified	LMNA; FABP3; FABP5; FABP2; FABP4; MAPT; THPO;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP1A2; CYP2A6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	GLA	Alpha-galactosidase A	P06280	CHEMBL2524
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 2 group B	RXRA	Retinoid X receptor alpha	P19793	CHEMBL2061
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
SLC superfamily of solute carriers	SLC6A2	Norepinephrine transporter	P23975	CHEMBL222
SLC superfamily of solute carriers	SLC6A3	Dopamine transporter	Q01959	CHEMBL238
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.021E-10	1.853E-07	BLM, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, PPARA, PPARD, RXRA, TP53
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.602E-07	1.828E-04	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0051001; negative regulation of nitric-oxide synthase activity	3.574E-07	2.432E-04	CNR1, CNR2, GLA
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	3.808E-07	2.513E-04	BLM, CA2, CA9, CNR1, CYP1A2, HPGD, MAPK1, NFKB1, SLC6A3, TLR2, TP53
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.237E-27	4.870E-23	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0050896; response to stimulus	GO:0035094; response to nicotine	2.030E-06	1.028E-03	CNR1, MAPK1, NFKB1, SLC6A3
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.229E-06	1.073E-03	CYP1A2, CYP2A6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0045471; response to ethanol	5.746E-06	2.195E-03	CA3, CNR1, HPGD, SLC6A3, TP53
BP	GO:0050896; response to stimulus	GO:0010038; response to metal ion	6.069E-06	2.278E-03	CA2, CYP1A2, FABP4, HIF1A, MAPK1, SLC6A3, TP53
BP	GO:0051179; localization	GO:0046903; secretion	1.292E-05	4.397E-03	ALOX5, CA2, CA9, FABP5, GAA, GLA, HIF1A, MAPK1, NFKB1, SLC6A3, TLR2
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.450E-05	4.654E-03	CA2, CA7
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	1.450E-05	4.654E-03	CNR1, CNR2
MF	GO:0005215; transporter activity	GO:0005330; dopamine:sodium symporter activity	1.450E-05	4.654E-03	SLC6A2, SLC6A3
BP	GO:0008152; metabolic process	GO:0009299; mRNA transcription	2.284E-05	6.544E-03	HIF1A, PPARD, TP53
MF	GO:0003824; catalytic activity	GO:0016712; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	2.578E-05	7.124E-03	CYP1A2, CYP2A6, CYP3A4
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	2.896E-05	7.419E-03	CNR1, CNR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.896E-05	7.419E-03	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0019902; phosphatase binding	3.078E-05	7.794E-03	MAPK1, MAPT, PPARA, SLC6A3, TP53
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	3.217E-05	7.923E-03	CNR1, CNR2, CYP1A2, HPGD, NFKB1, PPARD
BP	GO:0008152; metabolic process	GO:0046320; regulation of fatty acid oxidation	3.238E-05	7.923E-03	CNR1, FABP3, PPARA
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	3.238E-05	7.923E-03	MAPT, SLC6A3, TP53
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.202E-20	1.309E-16	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.354E-19	1.282E-15	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	5.612E-05	1.247E-02	CA2, CA4, CA9, HPGD, TSHR
CC	GO:0044464; cell part	GO:0043204; perikaryon	1.230E-04	2.060E-02	CNR2, MAPK1, SMN1, SMN2
CC	GO:0044464; cell part	GO:0042995; cell projection	1.709E-04	2.684E-02	CA2, CNR1, CNR2, HIF1A, MAPK1, MAPT, SLC6A2, SLC6A3, SMN1, SMN2, TLR2
CC	GO:0044464; cell part	GO:0030424; axon	2.554E-04	3.588E-02	CA2, CNR1, MAPK1, MAPT, SLC6A3

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	4.487E-07	5.609E-05	RXRA, MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	3.377E-06	2.110E-04	RXRA, MAPK1, TP53
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	6.931E-06	2.888E-04	RXRA, CA2, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	3.191E-05	9.308E-04	RXRA, MAPK1, TP53
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	5.316E-05	9.493E-04	LMNA, MAPK1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	4.562E-05	9.493E-04	RXRA, MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	3.133E-04	4.352E-03	MAPK1, MAPT, TP53
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.229E-04	3.483E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	3.592E-04	4.490E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	5.613E-04	4.818E-03	MAPK1, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4.167E-04	4.735E-03	FABP4, TSHR
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	5.108E-04	4.818E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	7.323E-04	4.818E-03	RXRA, MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	5.787E-04	4.818E-03	MAPK1, TP53
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.723E-05	9.308E-04	CA2, CA14
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.138E-03	6.464E-03	RXRA, MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	5.963E-04	4.818E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	6.694E-04	4.818E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	7.075E-04	4.818E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.049E-03	6.245E-03	MAPK1, TP53
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.323E-04	4.818E-03	RXRA, FABP4
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	9.802E-04	6.126E-03	RXRA, TP53
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	1.895E-03	9.871E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.895E-03	9.871E-03	MAPK1, TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
NA: NA	Edema	NA	CA2;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Cutaneous T-cell lymphoma	C84.0, C84.1	RXRA;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases