CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Enzyme_unclassified	ALOX15; HSD17B10; ALDH1A1; USP2;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	SERPINA6;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	2.946E-06	7.127E-03	PPARA, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	4.417E-06	8.015E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	4.417E-06	8.015E-03	PPARA, PPARG
BP	GO:0051179; localization	GO:0015908; fatty acid transport	6.452E-06	1.081E-02	PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	9.821E-06	1.426E-02	ALOX15, PPARA, PPARD
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	2.495E-06	6.792E-03	PPARA, PPARD, PPARG
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	4.389E-06	8.015E-03	PPARA, PPARD, PPARG
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	1.617E-05	1.877E-02	PPARD, PPARG
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	4.489E-05	2.962E-02	SLCO1B1, SLCO1B3
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	8.082E-05	4.562E-02	SLCO1B1, SLCO1B3

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2.609E-02	7.993E-02	HSD17B10
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.358E-02	7.993E-02	ALOX15
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.518E-02	7.993E-02	ALDH1A1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	3.997E-02	7.993E-02	PTPN1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.357E-06	1.653E-04	PPARG, PPARA, PPARD
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	6.694E-04	8.702E-03	SLCO1B1, SLCO1B3
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	3.784E-02	7.993E-02	PPARA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.568E-03	1.359E-02	PTPN1, PPARA
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.091E-02	7.993E-02	PPARD
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.689E-02	7.993E-02	ALOX15, ALDH1A1, HSD17B10

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Alstonia lanceolifera

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities