Plant Name: Pistacia mexicana
Taxonomic Information:
Plant ID: NPO13248
Plant Latin Name: Pistacia mexicana
Taxonomy Genus: Pistacia
Taxonomy Family: Anacardiaceae
Plant External Links:
NCBI TaxonomyDB:
246379
Plant-of-the-World-Online:
200169-2
Used in Medicines:
Unknown.
Geographical Distribution:
Honduras; Mexico
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TDP1; | |
| NR1H4; | |
| PPARA; | |
| MAOB; | |
| TLR2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Oxidoreductase | MAOB | Monoamine oxidase B | P27338 | CHEMBL2039 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051704; multi-organism process | GO:0002237; response to molecule of bacterial origin | 3.482E-05 | 1.610E-01 | MAOB, NR1H4, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0050727; regulation of inflammatory response | 7.805E-05 | 1.610E-01 | NR1H4, PPARA, TLR2 |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 6.274E-05 | 1.610E-01 | NR1H4, PPARA |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 9.118E-05 | 1.610E-01 | NR1H4, PPARA |
| MF | GO:0005488; binding | GO:0008289; lipid binding | 4.066E-04 | 1.789E-01 | NR1H4, PPARA, TLR2 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 7.764E-04 | 1.848E-01 | NR1H4 |
| CC | Unclassified; | GO:0106003; amyloid-beta complex | 2.844E-03 | 3.260E-01 | TLR2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00360 | Phenylalanine metabolism | 4.243E-03 | 4.190E-02 | MAOB |
| 09160 Human Diseases | 09164 Substance dependence | hsa05030 | Cocaine addiction | 1.219E-02 | 4.190E-02 | MAOB |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 1.368E-02 | 4.190E-02 | TLR2 |
| 09160 Human Diseases | 09164 Substance dependence | hsa05031 | Amphetamine addiction | 1.664E-02 | 4.190E-02 | MAOB |
| 09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 1.615E-02 | 4.190E-02 | TLR2 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.713E-02 | 4.190E-02 | MAOB |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 1.738E-02 | 4.190E-02 | PPARA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 1.812E-02 | 4.190E-02 | TLR2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.713E-02 | 4.190E-02 | PPARA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.763E-02 | 4.190E-02 | NR1H4 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
