CMAUP Plant Collective Molecular Activities

Plant Name: Sinomenium acutum

Taxonomic Information:

Plant ID: NPO1315
Plant Latin Name: Sinomenium acutum
Taxonomy Genus: Sinomenium
Taxonomy Family: Menispermaceae

Plant External Links:

NCBI TaxonomyDB: 152363
Plant-of-the-World-Online: 581373-1

Used in Medicines:

Country/Region:

Thailand; China

Traditional Medicine System:

TCM; Kampo

Medicinal Functions:

Anodyne; Carminative

Geographical Distribution:

South Africa; Nepal; India; China; Japan; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD5; DRD3; DRD4; DRD1; DRD2;
Enzyme_unclassified	BLM;
Hydrolase	ACHE;
Potassium channels	KCNH2;
Transcription Factor	TP53;
Unclassified	MAPT; HTT; F3; LMNA; SIGMAR1; RAD52;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Potassium channels	KCNH2	HERG	Q12809	CHEMBL240
Small molecule receptor (family A GPCR)	DRD5	Dopamine D5 receptor	P21918	CHEMBL1850
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	DRD4	Dopamine D4 receptor	P21917	CHEMBL219
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	SIGMAR1	Sigma opioid receptor	Q99720	CHEMBL287
Unclassified	RAD52	DNA repair protein RAD52 homolog	P43351	CHEMBL2362978

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0035240; dopamine binding	4.901E-13	5.336E-09	DRD1, DRD2, DRD3, DRD4, DRD5
BP	GO:0050896; response to stimulus	GO:0001975; response to amphetamine	2.487E-11	1.316E-07	DRD1, DRD2, DRD3, DRD4, DRD5
BP	GO:0007610; behavior	GO:0048148; behavioral response to cocaine	2.533E-09	3.940E-06	DRD1, DRD2, DRD3, DRD4
MF	GO:0060089; molecular transducer activity	GO:0001591; dopamine neurotransmitter receptor activity, coupled via Gi/Go	3.794E-08	3.592E-05	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0007191; adenylate cyclase-activating dopamine receptor signaling pathway	8.120E-08	5.052E-05	DRD1, DRD3, DRD5
BP	GO:0009987; cellular process	GO:0007195; adenylate cyclase-inhibiting dopamine receptor signaling pathway	8.120E-08	5.052E-05	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0034776; response to histamine	1.116E-07	6.394E-05	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0060134; prepulse inhibition	1.932E-07	9.348E-05	DRD1, DRD2, DRD3
BP	GO:0009987; cellular process	GO:0060158; phospholipase C-activating dopamine receptor signaling pathway	1.932E-07	9.348E-05	DRD1, DRD2, DRD5
BP	GO:0007610; behavior	GO:0046960; sensitization	8.202E-07	2.748E-04	DRD1, DRD5
BP	GO:0065007; biological regulation	GO:0006874; cellular calcium ion homeostasis	8.601E-07	2.838E-04	DRD1, DRD2, DRD3, DRD4, DRD5, HTT
BP	GO:0051179; localization	GO:0050482; arachidonic acid secretion	1.189E-06	3.408E-04	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0060160; negative regulation of dopamine receptor signaling pathway	2.459E-06	5.637E-04	DRD2, DRD3
BP	GO:0023052; signaling	GO:0051586; positive regulation of dopamine uptake involved in synaptic transmission	2.459E-06	5.637E-04	DRD2, DRD4
BP	GO:0065007; biological regulation	GO:0007194; negative regulation of adenylate cyclase activity	3.314E-06	7.215E-04	DRD2, DRD3, DRD4
CC	GO:0043226; organelle	GO:0097730; non-motile cilium	3.314E-06	7.215E-04	DRD1, DRD2, DRD5
BP	GO:0051179; localization	GO:1904064; positive regulation of cation transmembrane transport	4.328E-06	8.808E-04	DRD1, DRD4, HTT, KCNH2
MF	GO:0060089; molecular transducer activity	GO:0001588; dopamine neurotransmitter receptor activity, coupled via Gs	4.916E-06	9.731E-04	DRD1, DRD5
BP	GO:0065007; biological regulation	GO:0045776; negative regulation of blood pressure	7.625E-06	1.407E-03	DRD2, DRD3, DRD5
BP	Unclassified;	GO:0021853; cerebral cortex GABAergic interneuron migration	8.188E-06	1.438E-03	DRD1, DRD2
BP	GO:0040011; locomotion	GO:0090325; regulation of locomotion involved in locomotory behavior	8.188E-06	1.438E-03	DRD2, DRD3
BP	GO:0007610; behavior	GO:0008542; visual learning	1.145E-05	1.888E-03	DRD1, DRD2, DRD3
BP	Unclassified;	GO:0032415; regulation of sodium:proton antiporter activity	1.228E-05	1.923E-03	DRD3, DRD4
CC	GO:0044464; cell part	GO:0042995; cell projection	1.588E-05	2.384E-03	DRD1, DRD2, DRD3, DRD5, HTT, MAPT, SMN1, SMN2
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	1.971E-05	2.843E-03	ACHE, DRD2, DRD5, TP53
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	2.941E-05	4.106E-03	BLM, TP53
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	3.551E-05	4.778E-03	DRD1, DRD2, DRD3, HTT
BP	GO:0032501; multicellular organismal process	GO:0007416; synapse assembly	3.577E-05	4.778E-03	ACHE, DRD1, DRD2
MF	GO:0005488; binding	GO:0002039; p53 binding	3.577E-05	4.778E-03	BLM, HTT, TP53
BP	GO:0032501; multicellular organismal process	GO:0030432; peristalsis	3.675E-05	4.820E-03	DRD1, DRD2
MF	Unclassified;	GO:0004872; receptor activity	3.638E-05	4.820E-03	DRD1, DRD2, DRD3, DRD4, DRD5, F3, KCNH2, SIGMAR1
BP	GO:0009987; cellular process	GO:0002031; G-protein coupled receptor internalization	4.489E-05	5.617E-03	DRD2, DRD3
BP	GO:0032502; developmental process	GO:0021756; striatum development	4.489E-05	5.617E-03	DRD1, DRD2
MF	GO:0005488; binding	GO:0034452; dynactin binding	4.489E-05	5.617E-03	HTT, MAPT
BP	GO:0009987; cellular process	GO:0010821; regulation of mitochondrion organization	4.909E-05	5.906E-03	HTT, LMNA, MAPT, TP53
BP	GO:0007610; behavior	GO:0007625; grooming behavior	5.383E-05	6.235E-03	DRD1, DRD2
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	5.383E-05	6.235E-03	SMN1, SMN2
BP	GO:0051179; localization	GO:0002028; regulation of sodium ion transport	5.958E-05	6.758E-03	DRD2, DRD3, DRD4
CC	GO:0044422; organelle part	GO:0060170; ciliary membrane	5.958E-05	6.758E-03	DRD1, DRD2, DRD5
BP	GO:0007610; behavior	GO:0031223; auditory behavior	6.359E-05	7.101E-03	DRD2, HTT
BP	GO:0032501; multicellular organismal process	GO:0035815; positive regulation of renal sodium excretion	6.359E-05	7.101E-03	DRD2, DRD3
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	6.359E-05	7.101E-03	SMN1, SMN2
BP	GO:0007610; behavior	GO:0048149; behavioral response to ethanol	7.414E-05	8.032E-03	DRD2, DRD4
BP	GO:0023052; signaling	GO:0060292; long term synaptic depression	9.766E-05	9.996E-03	DRD1, DRD5

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	8.272E-08	5.542E-06	DRD1, DRD2, DRD3, DRD4, DRD5
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3.634E-06	1.217E-04	DRD1, DRD2, DRD3, DRD4, DRD5
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	7.092E-04	1.176E-02	DRD1, DRD2, DRD5
09120 Genetic Information Processing	09124 Replication and repair	hsa03440	Homologous recombination	3.062E-04	6.838E-03	RAD52, BLM
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	8.774E-04	1.176E-02	DRD1, DRD2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	2.797E-03	3.124E-02	DRD1, DRD2
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	6.916E-03	5.954E-02	LMNA, TP53
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05012	Parkinson's disease	7.109E-03	5.954E-02	DRD1, DRD2
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	1.028E-02	6.829E-02	SMN2, SMN1
09160 Human Diseases	09164 Substance dependence	hsa05034	Alcoholism	1.109E-02	6.829E-02	DRD1, DRD2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	TP53;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD5; DRD1; DRD3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	DRD1;
C00-D49: Neoplasms	Solid tumours	C00-D48	DRD5; TP53;
C00-D49: Neoplasms	Pancreatic cancer	C25	F3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1; DRD3;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD3;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1; DRD3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases