CMAUP Plant Collective Molecular Activities

Plant Name: Rhamnus davurica

Taxonomic Information:

Plant ID: NPO13054
Plant Latin Name: Rhamnus davurica
Taxonomy Genus: Rhamnus
Taxonomy Family: Rhamnaceae

Plant External Links:

NCBI TaxonomyDB: 105902
Plant-of-the-World-Online: 718301-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

United States; China; Russia; Mongolia; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA7; CA12;
Enzyme_unclassified	HSD17B10; HSD17B2;
Oxidoreductase	TYR;
Transcription Factor	AHR; NFKB1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.789E-11	3.896E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.080E-10	5.531E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.255E-08	5.464E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C9
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	3.222E-07	4.707E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.222E-07	4.707E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0020037; heme binding	8.739E-07	9.062E-04	CYP1A1, CYP1A2, CYP1B1, CYP2C9
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.121E-06	1.600E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.121E-06	1.600E-03	CYP1A2, CYP2C9
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.131E-06	1.600E-03	CYP1A1, CYP1A2, CYP1B1, CYP2C9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	5.300E-06	3.847E-03	CYP1A2, CYP2C9
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	9.886E-06	6.424E-03	CYP1A1, CYP1A2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.097E-08	2.230E-06	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.907E-08	2.847E-06	CYP2C9, CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.267E-07	3.041E-06	CYP2C9, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.610E-06	2.898E-05	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	3.184E-06	4.584E-05	HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7.059E-06	8.471E-05	CYP2C9, CYP1A2, CYP1A1
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.731E-05	3.838E-04	CYP2C9, HSD17B2, CYP1A2, CYP1A1, TYR, HSD17B10
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.571E-04	5.451E-03	CYP2C9, CYP1A2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.328E-04	1.062E-03	CYP2C9, CYP1A2
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.466E-05	4.019E-04	CA12, CA7

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
NA: NA	HIV infections	NA	AHR;
C00-D49: Neoplasms	Melanoma	C43	TYR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Multiple myeloma	C90	AHR;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	TYR;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases