CMAUP Plant Collective Molecular Activities

Plant Name: Allium stipitatum

Taxonomic Information:

Plant ID: NPO13010
Plant Latin Name: Allium stipitatum
Taxonomy Genus: Allium
Taxonomy Family: Amaryllidaceae

Plant External Links:

NCBI TaxonomyDB: 70767
Plant-of-the-World-Online: 528920-1

Used in Medicines:

Unknown.

Geographical Distribution:

Turkey; Afghanistan; Iran; Turkmenistan; Pakistan; Kazakhstan; Uzbekistan; Iraq; Tajikistan

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF; CDC25B;
Enzyme_unclassified	RECQL; HSD11B1; AKR1B10; IDO1; USP2; AOX1; GAPDH;
Protein Kinase	PRKCA;
Lyase	CA1; CA12; CA5B; CA5A; CA6;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	MAOB;
Metallo protease	MMP12; METAP2; MMP2;
Unclassified	HTT; LMNA; MAPT;
Methyl-lysine/arginine binding protein	L3MBTL1; SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP1A2; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	IDO1	Indoleamine 2,3-dioxygenase	P14902	CHEMBL4685
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Enzyme_unclassified	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase liver	P04406	CHEMBL2284
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	METAP2	Methionine aminopeptidase 2	P50579	CHEMBL3922
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	MAOB	Monoamine oxidase B	P27338	CHEMBL2039
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.297E-11	4.678E-07	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.351E-10	9.806E-07	CYP1A2, CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.249E-09	2.858E-05	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0005488; binding	GO:0008270; zinc ion binding	9.734E-09	4.239E-05	CA1, CA12, CA5A, CA5B, CA6, L3MBTL1, MMP12, MMP2, NR1H4, PRKCA, PTPN1, RORC
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.497E-08	5.431E-05	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	2.544E-07	5.541E-04	AKR1B10, CYP1A2, CYP2C19, CYP2C9, CYP2D6, HSD11B1, NR1H4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.483E-07	1.008E-03	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	9.178E-07	1.249E-03	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.186E-06	1.359E-03	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.186E-06	1.359E-03	CYP1A2, CYP2C9, CYP2D6
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.276E-06	1.390E-03	CYP1A2, CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.848E-06	1.701E-03	CYP1A2, CYP2C19, CYP2C9, CYP2D6, RORC
MF	GO:0005488; binding	GO:0020037; heme binding	3.270E-06	2.543E-03	CYP1A2, CYP2C19, CYP2C9, CYP2D6, IDO1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.088E-06	4.823E-03	CYP1A2, CYP2C19, CYP2C9
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	9.558E-06	6.052E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	9.558E-06	6.052E-03	GPBAR1, NR1H4
MF	GO:0005488; binding	GO:0005506; iron ion binding	9.727E-06	6.052E-03	AOX1, CYP1A2, CYP2C19, CYP2C9, CYP2D6

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.025E-09	1.073E-07	CYP2C9, MAOB, CYP2D6, CYP1A2, AOX1, CYP2C19
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	7.425E-11	7.870E-09	CA12, CA1, CA5B, CA5A, CA6
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	6.866E-07	2.426E-05	MAOB, CYP1A2, AOX1, IDO1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.429E-06	3.787E-05	CYP2C9, MAOB, CYP2D6, PRKCA, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.850E-06	1.664E-04	HSD11B1, CYP2C9, CYP2D6, CYP1A2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.247E-05	2.204E-04	HSD11B1, CYP2C9, CYP1A2, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.123E-04	2.501E-03	HSD11B1, CYP2C9, AKR1B10, MAOB, CYP1A2, AOX1, CYP2C19, GAPDH, IDO1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.739E-05	2.633E-04	CYP2C9, CYP1A2, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.991E-04	2.501E-03	CYP2C9, CYP1A2, AOX1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.923E-04	3.098E-03	PTPN1, ACP1, PTPRF

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOB;
NA: NA	Motor symptoms	NA	MAOB;
I00-I99: Diseases of the circulatory system	Moderate to severe hypertension	I10-I16	MAOB;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	MAOB;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAOB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOB;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAOB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	MAOB;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAOB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive episode without melancholia	F30-F39	MAOB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Idiopathic parkinson's disease	F02.3, G20	MAOB;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	MAOB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOB;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases