CMAUP Plant Collective Molecular Activities

Plant Name: Polypodium vulgare

Taxonomic Information:

Plant ID: NPO12993
Plant Latin Name: Polypodium vulgare
Taxonomy Genus: Polypodium
Taxonomy Family: Polypodiaceae

Plant External Links:

NCBI TaxonomyDB: 58048
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Turkey; Israel; Italy; Finland; India; Spain

Traditional Medicine System:

Medicinal Functions:

Alterative; Anthelmintic; Cholagogue; Demulcent; Diuretic; Expectorant; Pectoral; Purgative; Tonic

Geographical Distribution:

Turkey; Israel; Italy; Finland; India; Spain

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR2;
Peptide receptor (family A GPCR)	OPRD1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	AKR1B1; AKR1B10;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0044597; daunorubicin metabolic process	1.500E-06	1.050E-02	AKR1B1, AKR1B10
BP	GO:0008152; metabolic process	GO:0044598; doxorubicin metabolic process	1.500E-06	1.050E-02	AKR1B1, AKR1B10
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	2.027E-05	6.305E-02	AKR1B1, AKR1B10, NR1H4
MF	GO:0003824; catalytic activity	GO:0004033; aldo-keto reductase (NADP) activity	1.738E-05	6.305E-02	AKR1B1, AKR1B10
BP	GO:0032501; multicellular organismal process	GO:0019233; sensory perception of pain	7.348E-05	1.455E-01	CNR2, OPRD1
BP	GO:0050896; response to stimulus	GO:0009636; response to toxic substance	8.673E-05	1.574E-01	AKR1B1, CNR2, OPRD1
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	7.764E-04	2.562E-01	CNR2
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	7.764E-04	2.562E-01	NR1H4
CC	GO:0044464; cell part	GO:0005764; lysosome	1.949E-03	4.645E-01	AKR1B1, AKR1B10
CC	GO:0044464; cell part	GO:0042995; cell projection	3.316E-03	5.902E-01	AKR1B1, CNR2, OPRD1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3.139E-05	9.418E-05	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.169E-05	9.418E-05	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	8.507E-05	1.914E-04	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2.473E-05	9.418E-05	AKR1B10, AKR1B1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.859E-03	3.347E-03	OPRD1, CNR2
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.763E-02	2.644E-02	NR1H4
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.382E-02	3.805E-02	AKR1B10, AKR1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	2.965E-02	3.805E-02	OPRD1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	4.106E-02	4.106E-02	OPRD1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	CNR2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CNR2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	CNR2;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	CNR2;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	CNR2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CNR2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CNR2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases