CMAUP Plant Collective Molecular Activities

Plant Name: Rumex crispus

Taxonomic Information:

Plant ID: NPO12955
Plant Latin Name: Rumex crispus
Taxonomy Genus: Rumex
Taxonomy Family: Polygonaceae

Plant External Links:

NCBI TaxonomyDB: 174649
Plant-of-the-World-Online: 224413-2

Used in Medicines:

Country/Region:

Turkey; Italy; Portugal; South Africa; Mexico; India; South Korea; Russia

Traditional Medicine System:

Medicinal Functions:

Alterative; Antiscorbutic; Astringent; Cancer; Cholagogue; Depurative; Homeopathy; Laxative; Poultice; Salve; Tonic

Geographical Distribution:

Brazil; Turkey; Italy; Peru; Sudan; Costa Rica; France; Bahamas; Ethiopia; Norway; Ireland; Bolivia; Cameroon; Ecuador; Belarus; Algeria; Cuba; Iceland; Venezuela; Cape Verde; Russia; United States; Zimbabwe; Germany; Chile; Belgium; Dominican Republic; Spain; Ukraine; Eritrea; Netherlands; Libya; Denmark; Poland; Finland; New Caledonia; Mauritius; Morocco; Sweden; Namibia; Kenya; Switzerland; Honduras; Haiti; Bulgaria; Jamaica; Romania; Albania; Angola; Portugal; Mexico; Egypt; Fiji; South Africa; India; United Kingdom; Lesotho; Austria; Mozambique; Tunisia; Colombia; Greece; Hungary; South Korea; Cyprus; Zambia

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0038194; thyroid-stimulating hormone signaling pathway	2.071E-04	5.010E-01	TSHR
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	2.071E-04	5.010E-01	TSHR
BP	GO:0009987; cellular process	GO:0019896; axonal transport of mitochondrion	9.317E-04	8.115E-01	MAPT
BP	GO:0032501; multicellular organismal process	GO:0048143; astrocyte activation	9.317E-04	8.115E-01	MAPT
MF	GO:0005488; binding	GO:0034452; dynactin binding	1.139E-03	8.855E-01	MAPT
CC	GO:0044464; cell part	GO:0036464; cytoplasmic ribonucleoprotein granule	1.906E-02	1.000E+00	MAPT
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.917E-02	1.000E+00	TSHR
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	2.897E-03	1.000E+00	MAPT
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	3.311E-03	1.000E+00	MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	5.293E-03	1.654E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5.592E-03	1.654E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	7.088E-03	1.654E-02	TSHR
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.673E-02	2.751E-02	MAPT
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.980E-02	2.751E-02	TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	2.534E-02	2.751E-02	MAPT
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.751E-02	2.751E-02	TSHR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases