CMAUP Plant Collective Molecular Activities

Plant Name: Cabucala madagascariensis

Taxonomic Information:

Plant ID: NPO12952
Plant Latin Name: Cabucala madagascariensis
Taxonomy Genus: Cabucala
Taxonomy Family: Apocynaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; HTR7; HTR5A; ADRA1A; ADRB2; ADRB3; ADRA1D; ADRA2A; ADRA2B; DRD3; DRD2; HTR4; HTR1F; HTR1B; HTR1D; HTR1E; HTR2B; HTR2A; HTR1A; HTR2C; HTR6;
Peptide receptor (family A GPCR)	OPRD1; OPRM1;
Enzyme_unclassified	BLM; MPO; HSD17B10;
5HT3 receptor	HTR3A;
GABA-A receptor	GABRR1;
Plant homeodomain	KMT2A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
5HT3 receptor	HTR3A	Serotonin 3a (5-HT3a) receptor	P46098	CHEMBL1899
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	MPO	Myeloperoxidase	P05164	CHEMBL2439
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
GABA-A receptor	GABRR1	GABA receptor rho-1 subunit	P24046	CHEMBL3561
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Peptide receptor (family A GPCR)	OPRM1	Mu opioid receptor	P35372	CHEMBL233
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	HTR7	Serotonin 7 (5-HT7) receptor	P34969	CHEMBL3155
Small molecule receptor (family A GPCR)	HTR5A	Serotonin 5a (5-HT5a) receptor	P47898	CHEMBL3426
Small molecule receptor (family A GPCR)	ADRA1A	Alpha-1a adrenergic receptor	P35348	CHEMBL229
Small molecule receptor (family A GPCR)	ADRB2	Beta-2 adrenergic receptor	P07550	CHEMBL210
Small molecule receptor (family A GPCR)	ADRB3	Beta-3 adrenergic receptor	P13945	CHEMBL246
Small molecule receptor (family A GPCR)	ADRA1D	Alpha-1d adrenergic receptor	P25100	CHEMBL223
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Small molecule receptor (family A GPCR)	HTR4	Serotonin 4 (5-HT4) receptor	Q13639	CHEMBL1875
Small molecule receptor (family A GPCR)	HTR1F	Serotonin 1f (5-HT1f) receptor	P30939	CHEMBL1805
Small molecule receptor (family A GPCR)	HTR1B	Serotonin 1b (5-HT1b) receptor	P28222	CHEMBL1898
Small molecule receptor (family A GPCR)	HTR1D	Serotonin 1d (5-HT1d) receptor	P28221	CHEMBL1983
Small molecule receptor (family A GPCR)	HTR1E	Serotonin 1e (5-HT1e) receptor	P28566	CHEMBL2182
Small molecule receptor (family A GPCR)	HTR2B	Serotonin 2b (5-HT2b) receptor	P41595	CHEMBL1833
Small molecule receptor (family A GPCR)	HTR2A	Serotonin 2a (5-HT2a) receptor	P28223	CHEMBL224
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Small molecule receptor (family A GPCR)	HTR2C	Serotonin 2c (5-HT2c) receptor	P28335	CHEMBL225
Small molecule receptor (family A GPCR)	HTR6	Serotonin 6 (5-HT6) receptor	P50406	CHEMBL3371

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	4.096E-12	1.683E-09	HTR1A, HTR1B, HTR5A, HTR7
MF	GO:0005488; binding	GO:0051379; epinephrine binding	2.855E-10	9.869E-08	ADRA2A, ADRA2B, ADRB2, ADRB3
BP	GO:0009987; cellular process	GO:0002031; G-protein coupled receptor internalization	1.342E-09	4.003E-07	DRD2, DRD3, HTR1B, HTR2B
BP	GO:0008152; metabolic process	GO:0010513; positive regulation of phosphatidylinositol biosynthetic process	3.036E-08	7.266E-06	HTR2A, HTR2B, HTR2C
MF	GO:0005488; binding	GO:0051380; norepinephrine binding	3.036E-08	7.266E-06	ADRA2A, ADRB2, ADRB3
BP	GO:0009987; cellular process	GO:0014059; regulation of dopamine secretion	8.181E-08	1.665E-05	DRD2, DRD3, HTR1B, HTR2A
BP	GO:0065007; biological regulation	GO:0007194; negative regulation of adenylate cyclase activity	1.431E-07	2.757E-05	ADRA2A, DRD2, DRD3, OPRM1
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	4.074E-07	6.877E-05	ADRA1A, DRD2, HTR2A, HTR2B, HTR2C, OPRM1
BP	GO:0051179; localization	GO:0051209; release of sequestered calcium ion into cytosol	5.849E-07	9.434E-05	DRD2, HTR2A, HTR2B, HTR2C
BP	GO:0023052; signaling	GO:0051967; negative regulation of synaptic transmission, glutamatergic	1.095E-06	1.633E-04	DRD2, HTR1B, HTR2A
BP	GO:0009987; cellular process	GO:0007208; phospholipase C-activating serotonin receptor signaling pathway	2.176E-06	2.779E-04	HTR2A, HTR2C
MF	GO:0005488; binding	GO:0071886; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	2.176E-06	2.779E-04	HTR2A, HTR2C
MF	GO:0005488; binding	GO:0001965; G-protein alpha-subunit binding	2.901E-06	3.529E-04	HTR2A, HTR2B, OPRM1
BP	GO:0007610; behavior	GO:0048148; behavioral response to cocaine	3.409E-06	4.102E-04	DRD2, DRD3, HTR2A
BP	GO:0065007; biological regulation	GO:0007202; activation of phospholipase C activity	6.029E-06	6.767E-04	ADRA1A, HTR2A, HTR2B
BP	GO:0007610; behavior	GO:0007626; locomotory behavior	6.407E-06	7.067E-04	DRD2, DRD3, HTR2C, OPRD1, OPRM1
BP	GO:0009987; cellular process	GO:0060160; negative regulation of dopamine receptor signaling pathway	6.523E-06	7.067E-04	DRD2, DRD3
MF	GO:0060089; molecular transducer activity	GO:0004937; alpha1-adrenergic receptor activity	6.523E-06	7.067E-04	ADRA1A, ADRA1D
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	6.523E-06	7.067E-04	ADRA2A, ADRA2B
MF	GO:0005488; binding	GO:0051378; serotonin binding	9.916E-33	7.198E-29	HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR3A, HTR5A, HTR7
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	2.476E-29	5.990E-26	HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7
MF	GO:0060089; molecular transducer activity	GO:0004993; G-protein coupled serotonin receptor activity	2.476E-29	5.990E-26	HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7
MF	Unclassified;	GO:0004872; receptor activity	6.394E-24	7.734E-21	ADORA3, ADRA1A, ADRA1D, ADRA2A, ADRA2B, ADRB2, ADRB3, DRD2, DRD3, GABRR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR3A, HTR4, HTR5A, HTR6, HTR7, OPRD1, OPRM1
BP	GO:0007610; behavior	GO:0042755; eating behavior	9.719E-06	1.022E-03	ADRB3, OPRD1, OPRM1
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	1.303E-05	1.308E-03	ADRA2A, ADRA2B
BP	GO:0065007; biological regulation	GO:0001994; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	1.303E-05	1.308E-03	ADRA1A, ADRA1D
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	1.303E-05	1.308E-03	ADRA2A, ADRA2B
BP	GO:0032501; multicellular organismal process	GO:0014827; intestine smooth muscle contraction	1.303E-05	1.308E-03	HTR1D, HTR2B
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	1.328E-05	1.326E-03	DRD2, DRD3, HTR2A, HTR2B, HTR2C
BP	GO:0050896; response to stimulus	GO:0043278; response to morphine	1.466E-05	1.431E-03	DRD2, DRD3, OPRM1
BP	GO:0023052; signaling	GO:0032228; regulation of synaptic transmission, GABAergic	1.466E-05	1.431E-03	ADRA1A, DRD2, HTR1B
BP	Unclassified;	GO:0045907; positive regulation of vasoconstriction	1.610E-05	1.545E-03	ADRA1A, ADRA1D, HTR2A
BP	GO:0050896; response to stimulus	GO:0071312; cellular response to alkaloid	1.610E-05	1.545E-03	BLM, HTR1B, OPRM1
BP	GO:0032501; multicellular organismal process	GO:0045987; positive regulation of smooth muscle contraction	1.765E-05	1.678E-03	ADRA1A, ADRA1D, ADRA2B
BP	GO:0040011; locomotion	GO:0090325; regulation of locomotion involved in locomotory behavior	2.170E-05	1.986E-03	DRD2, DRD3
BP	GO:0050896; response to stimulus	GO:0071502; cellular response to temperature stimulus	2.170E-05	1.986E-03	HTR1B, HTR2B
BP	GO:0065007; biological regulation	GO:0007190; activation of adenylate cyclase activity	2.284E-05	2.072E-03	ADORA3, ADRB2, ADRB3
BP	GO:0009987; cellular process	GO:0050709; negative regulation of protein secretion	3.082E-05	2.728E-03	ADRA2A, DRD2, DRD3, OPRM1
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	3.474E-05	3.026E-03	ADRA1D, ADRA2A, DRD2, DRD3, HTR1A, HTR1B, HTR2A, HTR2B
BP	GO:0009987; cellular process	GO:0014062; regulation of serotonin secretion	4.549E-05	3.810E-03	HTR1A, HTR1B
BP	GO:0007610; behavior	GO:0008542; visual learning	5.029E-05	4.116E-03	DRD2, DRD3, KMT2A
BP	GO:0009987; cellular process	GO:0038003; opioid receptor signaling pathway	6.060E-05	4.679E-03	OPRD1, OPRM1
BP	GO:0032501; multicellular organismal process	GO:0031649; heat generation	6.060E-05	4.679E-03	ADRB2, ADRB3
BP	GO:0009987; cellular process	GO:0010700; negative regulation of norepinephrine secretion	6.060E-05	4.679E-03	ADRA2A, ADRA2B
BP	GO:0023052; signaling	GO:0051584; regulation of dopamine uptake involved in synaptic transmission	6.060E-05	4.679E-03	DRD2, DRD3
MF	GO:0060089; molecular transducer activity	GO:0004985; opioid receptor activity	6.060E-05	4.679E-03	OPRD1, OPRM1
MF	GO:0060089; molecular transducer activity	GO:0001591; dopamine neurotransmitter receptor activity, coupled via Gi/Go	6.060E-05	4.679E-03	DRD2, DRD3
BP	GO:0032501; multicellular organismal process	GO:0032922; circadian regulation of gene expression	7.574E-05	5.746E-03	DRD2, DRD3, KMT2A
BP	GO:0009987; cellular process	GO:0007191; adenylate cyclase-activating dopamine receptor signaling pathway	9.721E-05	7.083E-03	DRD3, OPRM1
BP	GO:0009987; cellular process	GO:0007195; adenylate cyclase-inhibiting dopamine receptor signaling pathway	9.721E-05	7.083E-03	DRD2, DRD3
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	1.067E-04	7.666E-03	ADRA2A, ADRB2, ADRB3, GABRR1, HTR3A
BP	GO:0050896; response to stimulus	GO:0034776; response to histamine	1.187E-04	8.400E-03	DRD2, DRD3
CC	GO:0044464; cell part	GO:0042995; cell projection	1.334E-04	9.253E-03	DRD2, DRD3, HTR2A, HTR2B, HTR3A, HTR5A, HTR6, OPRD1, OPRM1
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	3.566E-23	3.697E-20	ADORA3, ADRA1A, ADRA1D, ADRA2A, ADRA2B, ADRB2, ADRB3, DRD2, DRD3, GABRR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, OPRD1, OPRM1
BP	GO:0009987; cellular process	GO:0071880; adenylate cyclase-activating adrenergic receptor signaling pathway	6.006E-16	2.972E-13	ADRA1A, ADRA1D, ADRA2A, ADRA2B, ADRB2, ADRB3, DRD2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.008E-40	3.527E-39	OPRD1, HTR1E, HTR1F, HTR1D, HTR1A, HTR2B, HTR1B, HTR2C, ADRA1D, ADRB2, OPRM1, HTR2A, HTR5A, HTR4, ADRA2B, ADRA1A, ADRA2A, HTR6, GABRR1, HTR7, ADRB3, ADORA3, DRD2, DRD3
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.634E-22	2.860E-21	HTR1E, HTR1F, HTR1D, HTR1A, HTR2B, HTR1B, HTR2C, HTR3A, HTR2A, HTR5A, HTR4, HTR6, HTR7
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	6.930E-16	8.085E-15	HTR6, HTR7, ADRB3, HTR2B, HTR2C, ADRA1D, ADRB2, HTR2A, HTR5A, HTR4, ADRA1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	6.723E-12	5.882E-11	HTR6, HTR1E, HTR1F, HTR1D, HTR1A, HTR1B, ADRB2, HTR4, DRD2
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	7.382E-11	5.167E-10	OPRD1, ADRB3, ADORA3, ADRA1D, ADRB2, ADRA2B, ADRA1A, ADRA2A
09150 Organismal Systems	09157 Sensory system	hsa04742	Taste transduction	1.871E-09	1.091E-08	HTR1E, HTR1F, HTR1D, HTR1A, HTR1B, HTR3A
09150 Organismal Systems	09154 Digestive system	hsa04970	Salivary secretion	7.992E-06	3.496E-05	ADRB3, ADRA1D, ADRB2, ADRA1A
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	7.640E-06	3.496E-05	HTR2B, HTR2C, HTR2A, DRD2
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3.800E-04	1.478E-03	HTR2B, HTR2C, HTR2A
09150 Organismal Systems	09153 Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1.260E-03	4.410E-03	ADRA1D, ADRB2, ADRA1A
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2.978E-03	9.476E-03	ADRB3, ADRB2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
J00-J99: Diseases of the respiratory system	Asthma	J45	OPRM1; ADRB2; ADRB3; DRD2;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	MPO;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Post-traumatic stress disorder	F43.1	ADRA1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	ADRB2; OPRD1; HTR1A;
O00-O9A: Pregnancy, childbirth and the puerperium	Postpartum haemorrhage	O72	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fecal incontinence	R15	ADRA1D;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychosis	F20-F29	DRD2;
NA: NA	Peripheral vasoconstriction	NA	DRD2;
I00-I99: Diseases of the circulatory system	Peripheral vascular disease	I73.9	ADRA1D;
NA: NA	Peripheral sensory neuropathies	NA	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ADRA1A; DRD3; HTR1A;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	DRD2;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	OPRM1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Analgesia	R52, G89	OPRM1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe pain	R52, G89	OPRD1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Movement disorder	R25	OPRM1;
I00-I99: Diseases of the circulatory system	Coronary heart disease	I25.1	HTR2B;
NA: NA	Corneal vascularity	NA	DRD2;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD2; DRD3; HTR2C; HTR1A; HTR1B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychoses	F20-F29	HTR2B;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	ADRB3; DRD2;
NA: NA	Anxiety disorders	NA	HTR1A;
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	ADRA1D; HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2B; DRD2; OPRD1; HTR2A; HTR2C;
C00-D49: Neoplasms	Aggressive non-hodgkin's lymphoma	C81, C81-C86, C82-C85, C91-C95	HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Advanced stage Parkinson's disease	F02.3, G20	DRD2;
A00-B99: Certain infectious and parasitic diseases	Infections disease	A00-B99	MPO;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Idiopathic thrombocytopenic purpura	D69.3	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3; HTR2C;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	OPRM1; ADRA1A; ADRA1D; ADRB3; OPRD1; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Chronic schizophrenics	F20	HTR1B;
L00-L99: Diseases of the skin and subcutaneous tissue	Aging skin	L00-L99	ADRB2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	DRD2; HTR6; HTR1A;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	DRD2;
I00-I99: Diseases of the circulatory system	Hypotension	I95	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	ADRB3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	OPRM1;
NA: NA	False perceptions	NA	DRD2;
C00-D49: Neoplasms	Prostate cancer	C61	ADRA1A;
N00-N99: Diseases of the genitourinary system	Prostate hyperplasia	N40	ADRA1A; ADRA1D;
NA: NA	Vomiting	NA	DRD2; HTR3A;
NA: NA	Chronic diarrhea associated with inflammatory bowel disease	NA	OPRD1;
J00-J99: Diseases of the respiratory system	Chronic breathing disorders	J44-J47	ADRB2;
I00-I99: Diseases of the circulatory system	Maintain blood pressure in hypotensive states	I10	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HTR6;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR2A; HTR1A;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
N00-N99: Diseases of the genitourinary system	Bladder disease	N30-N32	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	DRD2;
NA: NA	Cervical dystonia	NA	HTR1A;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3; DRD2;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	HTR2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Erythropoietic porphyria	E80.0	HTR2A;
NA: NA	Episode	NA	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Erectile dysfunction	F52.2, N48.4	ADRA1D;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	HTR1D;
H00-H59: Diseases of the eye and adnexa	Ophthalmic disease	H00-H59	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A; DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	ADRB3; HTR1A; HTR1D;
NA: NA	Sleep initiation and maintenance disorders	NA	HTR2C;
L00-L99: Diseases of the skin and subcutaneous tissue	Skin infections	L00-L99	ADRB2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	OPRM1; ADRA1A; ADRA2A; DRD2; OPRD1; HTR2C; HTR1A;
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	DRD2; HTR2C; HTR1B; HTR1D;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	DRD2;
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	DRD2;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADRA1A; HTR6; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HTR7; HTR2A;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1; HTR1D;
NA: NA	Acute nonspecific diarrhea	NA	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep maintenance insomnia	F51.0, G47.0	HTR2A;
NA: NA	Exacerbations of acute asthma	NA	ADRB2;
NA: NA	Social phobia	NA	HTR1A;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MPO; ADRB2; ADRB3; DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	ADRB2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cancer pain	R52, G89	OPRM1;
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3;
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	DRD2;
NA: NA	Bulimia nervosa	NA	HTR1A;
J00-J99: Diseases of the respiratory system	Bronchodilator	J45	ADRB2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Mild pain	R52, G89	OPRM1;
NA: NA	Schizoaffective disorder	NA	HTR1A;
NA: NA	Schizoaffective disorders	NA	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	OPRM1;
NA: NA	Bradycardia	NA	ADRB2;
C00-D49: Neoplasms	Breast cancer	C50	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
J00-J99: Diseases of the respiratory system	Acute asthma	J45	ADRB2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD2; DRD3; HTR6; HTR3A;
I00-I99: Diseases of the circulatory system	Cardiotonic	I50	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR7; DRD2; DRD3; HTR2A; HTR2C; HTR6; HTR1A;
NA: NA	Benign prostatic hypertrophy	NA	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MPO; DRD2; HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	OPRM1; ADRB2; ADRB3; HTR2C; HTR6;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	OPRM1; DRD2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA1A; ADORA3; ADRA1D; ADRB3; DRD2; HTR2A;
N00-N99: Diseases of the genitourinary system	Benign prostatic hyperplasia	N40	ADRA1A; ADRA1D;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	HTR6;
N00-N99: Diseases of the genitourinary system	Neurogenic bladder dysfunction	N31.9	ADRB2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADRA2B;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR2C; HTR6;
A00-B99: Certain infectious and parasitic diseases	Diarrhea	A09, K59.1	OPRM1;
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1;
K00-K95: Diseases of the digestive system	Gastroesophageal reflux disease	K21	HTR3A;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	OPRM1; ADRB3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	General anesthesia	R20.0	OPRM1;
K00-K95: Diseases of the digestive system	Gastrointestinal problems	K30-K31, Q40-Q41	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR2C; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR2A; HTR2B; HTR2C; HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Acromegaly	E22.0	DRD2;
J00-J99: Diseases of the respiratory system	Nasal congestion	J34.89	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	DRD2; HTR3A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	OPRD1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRB2;
NA: NA	Heart block	NA	ADRB2;
G00-G99: Diseases of the nervous system G00-G99	Headache	G43-G44, R51	OPRM1;
NA: NA	Malignant phaeochromocytoma	NA	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	ADRA1A; ADRA1D;
O00-O9A: Pregnancy, childbirth and the puerperium	Premature labour	O60.1, P07.3	ADRB2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADRA1D; ADRB3; HTR2A; HTR2C;
K00-K95: Diseases of the digestive system	Dermal necrosis	K05	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperprolactinemia	E22.1	DRD2;
K00-K95: Diseases of the digestive system	Constipation	K59.0	OPRM1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe acute pain	R52, G89	OPRM1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	DRD2;
NA: NA	Inflammatory diseases	NA	DRD2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	OPRM1; MPO; DRD2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	DRD2;
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	HTR2A;
C00-D49: Neoplasms	Pediatric cancer	C00-C96	ADRA1D;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR2A; HTR2C; HTR1A; HTR1B; HTR1D;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	OPRM1; HTR2A; HTR2B; HTR1F; HTR1A; HTR1D;
NA: NA	Itching	NA	DRD2;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	ADRB3; HTR2B; HTR3A;
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	ADRB3; OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Narcotic depression	F19.20, F32	OPRM1;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	HTR2A; HTR3A;
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A;
K00-K95: Diseases of the digestive system	Opioid-induced constipation	K59.0	OPRM1;
I00-I99: Diseases of the circulatory system	Pulmonary hypertension	I27.0, I27.2	DRD2;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA1A; ADRA1D; ADRB2; ADRB3; DRD2; HTR1A;
NA: NA	Primary insomnia	NA	HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	DRD2; OPRD1; HTR2A; HTR2C; HTR6; HTR1A; HTR1B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Opiate dependence	F11	OPRM1;
E00-E89: Endocrine, nutritional and metabolic diseases	Carcinoid syndrome	E34.0	DRD2;
NA: NA	Addiction	NA	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	DRD2;
NA: NA	Hyperaemia	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRM1; HTR7; ADRA1A; ADRB3; DRD2; OPRD1; HTR2C; HTR1A; HTR1B; HTR1D;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD2;
N00-N99: Diseases of the genitourinary system	Stress urinary incontinence	N39.3	ADRA1A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Systemic pain	R52, G89	OPRM1;
I00-I99: Diseases of the circulatory system	Hemorrhoids	I84	HTR2A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Depressive fatigue	R53.82	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Local anaesthetic	R20.0	HTR3A;
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	HTR2B;
NA: NA	Malignant essential hypertension	NA	DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases