CMAUP Plant Collective Molecular Activities

Plant Name: Gymnadenia conopsea

Taxonomic Information:

Plant ID: NPO12933
Plant Latin Name: Gymnadenia conopsea
Taxonomy Genus: Gymnadenia
Taxonomy Family: Orchidaceae

Plant External Links:

NCBI TaxonomyDB: 59324
Plant-of-the-World-Online: 636509-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Demulcent; Nutritive

Geographical Distribution:

Turkey; Italy; Nepal; Mongolia; France; Ireland; Norway; Belarus; Iran; China; Belgium; Germany; Spain; Ukraine; Netherlands; Denmark; Poland; Finland; United States; Sweden; Japan; Switzerland; Russia; Bulgaria; Romania; Albania; Portugal; South Africa; United Kingdom; Austria; Greece; Hungary

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	ALDH1A1;
Unclassified	MAPT; MITF; NPC1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	MITF	Microphthalmia-associated transcription factor	O75030	CHEMBL1741165
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	Unclassified;	GO:2000188; regulation of cholesterol homeostasis	1.363E-05	9.890E-02	NPC1, NR1H4
BP	GO:0008152; metabolic process	GO:0006066; alcohol metabolic process	1.532E-04	2.909E-01	ALDH1A1, CYP3A4, NPC1
CC	GO:0044464; cell part	GO:0005764; lysosome	5.306E-03	8.297E-01	NPC1, RAB9A
CC	GO:0044464; cell part	GO:0030673; axolemma	6.609E-03	9.120E-01	MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.876E-04	3.775E-03	ALDH1A1, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.431E-04	3.775E-03	NR1H4, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.154E-02	5.767E-02	CYP3A4
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	2.101E-02	5.767E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2.219E-02	5.767E-02	TSHR
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	2.805E-02	5.767E-02	MITF
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.727E-02	5.767E-02	CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.297E-02	5.767E-02	CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	2.805E-02	5.767E-02	TSHR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.883E-02	5.767E-02	CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases