CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	BLM; AOX1;
Protein Kinase	EGFR;
Nuclear hormone receptor subfamily 3 group A	ESR2; ESR1;
Nuclear hormone receptor subfamily 3 group B	ESRRB; ESRRA;
Oxidoreductase	ALDH2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group B	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751
Nuclear hormone receptor subfamily 3 group B	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Oxidoreductase	ALDH2	Aldehyde dehydrogenase	P05091	CHEMBL1935
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	3.987E-07	1.085E-03	ESR1, ESR2, ESRRA, ESRRB
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	9.160E-07	2.216E-03	ESR1, ESR2, ESRRA, ESRRB
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	1.310E-06	2.853E-03	ESR1, ESR2, ESRRA, ESRRB
MF	GO:0005488; binding	GO:0005496; steroid binding	7.535E-08	3.282E-04	ESR1, ESR2, ESRRA, ESRRB
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	2.412E-07	7.504E-04	ESR1, ESR2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	1.447E-06	2.864E-03	ESR1, ESR2
MF	GO:0098772; molecular function regulator	GO:0030235; nitric-oxide synthase regulator activity	5.059E-06	7.175E-03	EGFR, ESR1

Showing 1 to 7 of 7 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.737E-04	5.683E-03	ALDH2, AOX1
09100 Metabolism	09105 Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2.507E-04	5.683E-03	ALDH2, AOX1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.602E-04	6.398E-03	CYP2C9, AOX1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5.185E-04	6.398E-03	CYP2C9, AOX1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.377E-05	9.361E-04	ESR1, EGFR, ESR2
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	5.645E-04	6.398E-03	ESR1, ESR2

Showing 1 to 6 of 6 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
C00-D49: Neoplasms	Cancer	C00-C96	ESR1; EGFR;
C00-D49: Neoplasms	Ovarian cancer	C56	EGFR;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1;
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1; EGFR;
C00-D49: Neoplasms	Prostate cancer	C61	ESR1; EGFR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Astragalus bicuspis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities