Plant Name: Sarcococca hookeriana
Taxonomic Information:
Plant ID: NPO12900
Plant Latin Name: Sarcococca hookeriana
Taxonomy Genus: Sarcococca
Taxonomy Family: Buxaceae
Plant External Links:
NCBI TaxonomyDB:
153579
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Hydrolase | BCHE | Butyrylcholinesterase | P06276 | CHEMBL1914 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0003990; acetylcholinesterase activity | 1.608E-08 | 3.502E-04 | ACHE, BCHE |
| MF | GO:0005488; binding | GO:0001540; amyloid-beta binding | 2.841E-05 | 1.409E-01 | ACHE, BCHE |
| BP | GO:0008152; metabolic process | GO:0042133; neurotransmitter metabolic process | 6.138E-05 | 1.909E-01 | ACHE, BCHE |
| CC | GO:0044464; cell part | GO:0005641; nuclear envelope lumen | 1.242E-03 | 9.326E-01 | BCHE |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 2.861E-02 | 1.000E+00 | SLCO1B3 |
| MF | GO:0005215; transporter activity | GO:0015347; sodium-independent organic anion transmembrane transporter activity | 3.723E-03 | 1.000E+00 | SLCO1B3 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 1.656E-02 | 1.656E-02 | ACHE |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.061E-02 | 1.656E-02 | SLCO1B3 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00564 | Glycerophospholipid metabolism | 1.418E-02 | 1.656E-02 | ACHE |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
