CMAUP Plant Collective Molecular Activities

Plant Name: Citrus aurantiifolia

Taxonomic Information:

Plant ID: NPO12807
Plant Latin Name: Citrus aurantiifolia
Taxonomy Genus: Citrus
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 159033
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Brazil; Tanzania; Indonesia; India; Burkina Faso; Togo; Rwanda; Kenya; Thailand; Nigeria; Iraq; Philippines

Traditional Medicine System:

Indian Folk; Unani; Ayurveda; Siddha

Geographical Distribution:

Brazil; Philippines; Indonesia; India; Togo; Rwanda; Tanzania; Thailand; Kenya; Nigeria; Iraq; Burkina Faso

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Transient receptor potential channel	TRPA1;
Lyase	CA2; CA1; CA7; CA9; CA13;
Unclassified	LMNA; RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.687E-14	3.672E-10	CA1, CA13, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.110E-12	2.297E-08	CA1, CA13, CA2, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.069E-12	4.405E-08	CA1, CA13, CA2, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.788E-07	1.400E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.892E-06	4.198E-03	CA1, CA2
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.427E-05	1.721E-02	CA1, CA13, CA2, CA7, CA9
CC	GO:0044464; cell part	GO:0043209; myelin sheath	2.000E-03	8.215E-01	CA13, CA2
CC	GO:0044464; cell part	GO:0032421; stereocilium bundle	2.328E-03	9.092E-01	TRPA1
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	2.451E-03	9.357E-01	LMNA, NPC1
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.176E-03	9.990E-01	CA2, CA9
CC	GO:0043226; organelle	GO:1903561; extracellular vesicle	3.129E-02	1.000E+00	CA1, CA2, NPC1, RAB9A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.919E-14	3.795E-13	CA1, CA2, CA7, CA9, CA13
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	1.209E-02	5.238E-02	CA2
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.030E-02	5.238E-02	CA2
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	3.282E-02	5.623E-02	CA2
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.151E-02	5.623E-02	CA2
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	3.282E-02	5.623E-02	LMNA
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4.325E-02	5.623E-02	TRPA1
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	3.674E-02	5.623E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	3.979E-02	5.623E-02	LMNA
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	4.239E-02	5.623E-02	CA2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases