CMAUP Plant Collective Molecular Activities

Plant Name: Stephania tetrandra

Taxonomic Information:

Plant ID: NPO12773
Plant Latin Name: Stephania tetrandra
Taxonomy Genus: Stephania
Taxonomy Family: Menispermaceae

Plant External Links:

NCBI TaxonomyDB: 425106
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	BLM; USP2;
Hydrolase	GAA; ACHE;
Potassium channels	KCNH2;
Unclassified	MAPT; HTT; LMNA; RAD52;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Potassium channels	KCNH2	HERG	Q12809	CHEMBL240
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAD52	DNA repair protein RAD52 homolog	P43351	CHEMBL2362978

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0042802; identical protein binding	3.696E-08	8.049E-04	ACHE, BLM, HTT, KCNH2, MAPT, RAD52, SMN1, SMN2, USP2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09120 Genetic Information Processing	09124 Replication and repair	hsa03440	Homologous recombination	1.328E-04	3.187E-03	RAD52, BLM
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	4.586E-03	5.503E-02	SMN2, SMN1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.727E-02	7.791E-02	CYP3A4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3.310E-02	7.791E-02	GAA
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2.726E-02	7.791E-02	CYP3A4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.786E-02	7.791E-02	GAA
09120 Genetic Information Processing	09124 Replication and repair	hsa03460	Fanconi anemia pathway	3.135E-02	7.791E-02	BLM
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.294E-02	7.791E-02	CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.179E-02	7.791E-02	CYP3A4
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	4.352E-02	7.791E-02	LMNA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases