CMAUP Plant Collective Molecular Activities

Plant Name: Ajuga australis

Taxonomic Information:

Plant ID: NPO12738
Plant Latin Name: Ajuga australis
Taxonomy Genus: Ajuga
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Australia

Traditional Medicine System:

Medicinal Functions:

Salve

Geographical Distribution:

Australia

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA1; CA5B; CA5A; CA6; CA12;
Unclassified	HTT; RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	7.499E-15	1.633E-10	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	9.388E-13	1.022E-08	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.702E-12	1.961E-08	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.573E-06	1.193E-02	CA1, CA12, CA5A, CA5B, CA6
CC	GO:0043226; organelle	GO:0042470; melanosome	4.108E-02	1.000E+00	RAB9A
MF	GO:0005488; binding	GO:0043169; cation binding	1.520E-02	1.000E+00	CA1, CA12, CA5A, CA5B, CA6

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.298E-14	5.193E-14	CA12, CA1, CA5B, CA5A, CA6
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	4.816E-02	7.084E-02	NPC1
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	5.313E-02	7.084E-02	RAB9A
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05016	Huntington's disease	7.465E-02	7.465E-02	HTT

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases