CMAUP Plant Collective Molecular Activities

Plant Name: Liriodendron tulipifera

Taxonomic Information:

Plant ID: NPO12721
Plant Latin Name: Liriodendron tulipifera
Taxonomy Genus: Liriodendron
Taxonomy Family: Magnoliaceae

Plant External Links:

NCBI TaxonomyDB: 3415
Plant-of-the-World-Online: 30197364-2

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

Indian Folk; TCM

Medicinal Functions:

Anthelmintic; Aphrodisiac; Cardiac; Diuretic; Nervine; Poultice; Tonic

Geographical Distribution:

Canada; India; Georgia; China; United States

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ACHE;
Enzyme_unclassified	TDP1; HSD17B1; GFER; NOX4;
Protein Kinase	FLT3; CDK8; CSNK2A1;
Lyase	CA2; CA12; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 1 group A	THRB;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Oxidoreductase	PTGS2;
Metallo protease	MMP9; MMP1; MMP12; MMP2;
Transcription Factor	HIF1A; NFKB1;
Bromodomain	CREBBP;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C19; CYP2C9; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Bromodomain	CREBBP	CREB-binding protein	Q92793	CHEMBL5747
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK8	Cell division protein kinase 8	P49336	CHEMBL5719
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.465E-13	4.862E-09	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, NOX4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.595E-12	1.158E-08	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0020037; heme binding	1.544E-11	8.232E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, NOX4, PTGS2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.890E-11	8.232E-08	CA12, CA14, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.273E-10	3.959E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.625E-09	1.030E-05	CA12, CA14, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.800E-08	2.178E-05	CA12, CA2, CA4, CA7, CREBBP, ESR2, MMP1, MMP12, MMP2, MMP9, THRB
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	4.100E-08	4.464E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	6.740E-08	6.829E-05	CYP1A2, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.481E-07	1.168E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	2.030E-07	1.474E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.122E-07	1.491E-04	CYP19A1, CYP1A1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.690E-07	1.830E-04	CA12, CA2, CA4, CA7
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	5.782E-07	3.383E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	7.367E-07	4.011E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	2.486E-06	1.128E-03	CREBBP, CYP1A1, HIF1A, MMP2, NOX4, PTGS2
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	2.996E-06	1.305E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	5.863E-06	2.280E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	6.550E-06	2.470E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.989E-06	2.495E-03	CA2, CA7
BP	GO:0032501; multicellular organismal process	GO:0010575; positive regulation of vascular endothelial growth factor production	9.642E-06	3.134E-03	CYP1B1, HIF1A, PTGS2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.396E-05	4.223E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.396E-05	4.223E-03	CYP1A2, CYP2C9
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	1.417E-05	4.226E-03	CYP1A1, CYP1B1, FLT3, NFKB1, NOX4, PTGS2
BP	GO:0022414; reproductive process	GO:0007566; embryo implantation	2.749E-05	7.700E-03	MMP2, MMP9, PTGS2
MF	GO:0003824; catalytic activity	GO:0004222; metalloendopeptidase activity	2.899E-05	7.891E-03	MMP1, MMP12, MMP2, MMP9

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.267E-11	3.398E-09	CA12, CA2, CA4, CA7, CA14
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.081E-08	3.747E-07	HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.165E-09	1.126E-07	CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP2C19, PTGS2
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	8.971E-08	1.866E-06	CREBBP, FLT3, MMP1, MMP2, PTGS2, HIF1A, MMP9, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.318E-08	6.027E-07	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.165E-06	7.220E-05	CYP2C9, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.898E-05	3.610E-04	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	7.338E-05	7.631E-04	CREBBP, CYP1B1, PTGS2, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	3.124E-05	3.610E-04	MMP1, MMP2, MMP9
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.084E-05	1.610E-04	CYP2C9, CYP1A2, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.085E-04	1.026E-03	CYP2C9, CYP2C19, PTGS2
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.249E-04	1.083E-03	CYP2C9, CYP1A2, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.493E-04	1.194E-03	CYP2C9, CYP1A2, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	4.335E-04	3.005E-03	MMP2, MMP9, ESR2
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	3.608E-04	2.680E-03	CSNK2A1, PTGS2, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	4.868E-04	3.164E-03	CREBBP, HIF1A, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	5.898E-04	3.403E-03	PTGS2, MMP9, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	6.217E-04	3.403E-03	CYP2C9, CYP2C19, PTGS2
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	7.236E-04	3.763E-03	CREBBP, THRB, HIF1A
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.339E-03	6.631E-03	CREBBP, MMP9, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.987E-03	9.394E-03	CYP2C9, HSD17B1, CYP1A2, CYP1A1, PTGS2, CYP2C19, CYP19A1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.396E-04	3.301E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PTGS2; CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
NA: NA	Upper abdominal bloating	NA	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12; PTGS2;
C00-D49: Neoplasms	Cancer	C00-C96	CSNK2A1; NFKB1; FLT3; ACHE; HIF1A; MMP9; PTGS2; MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; PTGS2;
NA: NA	Joint and muscular pain	NA	PTGS2;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	THRB;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	FLT3; CREBBP;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PTGS2;
NA: NA	GIST	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
S00-T88: Injury, poisoning and certain other consequences of external causes	Wound healing	T14.0-T14.1	THRB;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypothyroidism	E03	THRB;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; PTGS2;
C00-D49: Neoplasms	AML	NA	FLT3;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	High cholesterol levels in blood	E78.0	THRB;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	FLT3; MMP9;
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PTGS2; MMP1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperthyroidism	E05	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	THRB;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE; PTGS2;
C00-D49: Neoplasms	Pancreatic cancer	C25	FLT3; PTGS2; MMP2;
C00-D49: Neoplasms	Chronic myeloid leukemia	NA	CREBBP;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12; PTGS2;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS2; MMP2;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PTGS2; MMP1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Solid tumours	C00-D48	FLT3; HIF1A; MMP9; MMP2;
C00-D49: Neoplasms	Breast cancer	C50	FLT3; CYP19A1;
NA: NA	Rheumatold arthritis	NA	PTGS2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS2;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	CLL	NA	FLT3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases