CMAUP Plant Collective Molecular Activities

Plant Name: Ligularia altaica

Taxonomic Information:

Plant ID: NPO12711
Plant Latin Name: Ligularia altaica
Taxonomy Genus: Ligularia
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	TAAR1;
Hydrolase	ACHE;
Isomerase	TOP1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Isomerase	TOP1	DNA topoisomerase I	P11387	CHEMBL1781
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Small molecule receptor (family A GPCR)	TAAR1	Trace amine-associated receptor 1	Q96RJ0	CHEMBL5857

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006260; DNA replication	6.708E-04	1.000E+00	ACHE, TOP1
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.103E-03	1.000E+00	CYP2A6
BP	GO:0032501; multicellular organismal process	GO:0002076; osteoblast development	4.393E-03	1.000E+00	ACHE
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.425E-03	1.000E+00	CYP2A6
BP	GO:0008152; metabolic process	GO:0006796; phosphate-containing compound metabolic process	8.963E-03	1.000E+00	ACHE, TAAR1, TOP1
BP	GO:0008152; metabolic process	GO:0042136; neurotransmitter biosynthetic process	1.185E-02	1.000E+00	ACHE
BP	GO:0008152; metabolic process	GO:0031623; receptor internalization	1.416E-02	1.000E+00	ACHE
BP	GO:0032501; multicellular organismal process	GO:0032922; circadian regulation of gene expression	1.416E-02	1.000E+00	TOP1
BP	GO:0032501; multicellular organismal process	GO:0007416; synapse assembly	1.799E-02	1.000E+00	ACHE
BP	GO:0008152; metabolic process	GO:0044255; cellular lipid metabolic process	2.263E-02	1.000E+00	ACHE, CYP2A6
BP	GO:0009987; cellular process	GO:0051262; protein tetramerization	3.748E-02	1.000E+00	ACHE
BP	GO:0008152; metabolic process	GO:0018105; peptidyl-serine phosphorylation	4.199E-02	1.000E+00	TOP1
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	4.549E-02	1.000E+00	ACHE
CC	GO:0044464; cell part	GO:0043204; perikaryon	2.942E-02	1.000E+00	TOP1
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	5.177E-04	1.000E+00	ACHE
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	5.177E-04	1.000E+00	CYP2A6
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	4.393E-03	1.000E+00	CYP2A6
MF	GO:0003824; catalytic activity	GO:0016712; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	6.713E-03	1.000E+00	CYP2A6
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	8.771E-03	1.000E+00	CYP2A6
MF	GO:0005488; binding	GO:0043621; protein self-association	1.390E-02	1.000E+00	ACHE
MF	GO:0005488; binding	GO:0001540; amyloid-beta binding	1.544E-02	1.000E+00	ACHE
MF	GO:0005488; binding	GO:0001046; core promoter sequence-specific DNA binding	2.866E-02	1.000E+00	TOP1
MF	GO:0005488; binding	GO:0020037; heme binding	3.270E-02	1.000E+00	CYP2A6
MF	GO:0005488; binding	GO:0005506; iron ion binding	4.074E-02	1.000E+00	CYP2A6

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.250E-03	1.250E-02	CYP2A6
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.145E-02	3.361E-02	CYP2A6
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.615E-02	3.361E-02	CYP2A6
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.713E-02	3.361E-02	CYP2A6
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.812E-02	3.361E-02	CYP2A6
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	2.745E-02	3.431E-02	ACHE
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.033E-02	3.361E-02	CYP2A6
09100 Metabolism	09103 Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2.353E-02	3.361E-02	ACHE
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6.736E-02	7.485E-02	TAAR1
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.737E-01	2.737E-01	CYP2A6

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases