CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	TAAR1;
Hydrolase	ACHE;
Isomerase	TOP1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Isomerase	TOP1	DNA topoisomerase I	P11387	CHEMBL1781
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Small molecule receptor (family A GPCR)	TAAR1	Trace amine-associated receptor 1	Q96RJ0	CHEMBL5857

Showing 1 to 5 of 5 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006260; DNA replication	6.708E-04	1.000E+00	ACHE, TOP1
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.103E-03	1.000E+00	CYP2A6
BP	GO:0032501; multicellular organismal process	GO:0002076; osteoblast development	4.393E-03	1.000E+00	ACHE
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.425E-03	1.000E+00	CYP2A6
BP	GO:0008152; metabolic process	GO:0006796; phosphate-containing compound metabolic process	8.963E-03	1.000E+00	ACHE, TAAR1, TOP1
BP	GO:0008152; metabolic process	GO:0042136; neurotransmitter biosynthetic process	1.185E-02	1.000E+00	ACHE
BP	GO:0008152; metabolic process	GO:0031623; receptor internalization	1.416E-02	1.000E+00	ACHE
BP	GO:0032501; multicellular organismal process	GO:0032922; circadian regulation of gene expression	1.416E-02	1.000E+00	TOP1
BP	GO:0032501; multicellular organismal process	GO:0007416; synapse assembly	1.799E-02	1.000E+00	ACHE
BP	GO:0008152; metabolic process	GO:0044255; cellular lipid metabolic process	2.263E-02	1.000E+00	ACHE, CYP2A6

Showing 1 to 10 of 24 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.250E-03	1.250E-02	CYP2A6
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.145E-02	3.361E-02	CYP2A6
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.615E-02	3.361E-02	CYP2A6
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.713E-02	3.361E-02	CYP2A6
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.812E-02	3.361E-02	CYP2A6
09100 Metabolism	09103 Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2.353E-02	3.361E-02	ACHE
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6.736E-02	7.485E-02	TAAR1
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	2.745E-02	3.431E-02	ACHE
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.033E-02	3.361E-02	CYP2A6
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.737E-01	2.737E-01	CYP2A6

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Ligularia altaica

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities