Plant ID: NPO12707
Plant Latin Name: Lithospermum canescens
Taxonomy Genus: Lithospermum
Taxonomy Family: Boraginaceae
NCBI TaxonomyDB:
650305
Plant-of-the-World-Online:
117981-1
Unknown.
United States
Cytochrome P450 Enzymes: |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0005488; binding | GO:0008270; zinc ion binding | 3.976E-10 | 7.870E-07 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 7.235E-07 | 9.267E-04 | CA2, CA7 |
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 4.860E-29 | 1.058E-24 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 3.614E-06 | 4.142E-03 | CA1, CA2 |
BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 6.874E-24 | 7.484E-20 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.830E-21 | 1.232E-17 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
BP | GO:0051179; localization | GO:2001225; regulation of chloride transport | 1.083E-05 | 1.072E-02 | CA2, CA7 |
BP | GO:0023052; signaling | GO:0032230; positive regulation of synaptic transmission, GABAergic | 1.876E-05 | 1.776E-02 | CA2, CA7 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 1.725E-28 | 1.208E-27 | CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14 |
09150 Organismal Systems | 09155 Excretory system | hsa04966 | Collecting duct acid secretion | 1.342E-02 | 3.132E-02 | CA2 |
09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 1.144E-02 | 3.132E-02 | CA2 |
09150 Organismal Systems | 09154 Digestive system | hsa04971 | Gastric acid secretion | 3.640E-02 | 5.096E-02 | CA2 |
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 3.495E-02 | 5.096E-02 | CA2 |
09150 Organismal Systems | 09154 Digestive system | hsa04972 | Pancreatic secretion | 4.699E-02 | 5.482E-02 | CA2 |
09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05016 | Huntington's disease | 9.244E-02 | 9.244E-02 | HTT |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9; |
C00-D49: Neoplasms | Renal cancer | C64 | CA9; |
C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9; |
C00-D49: Neoplasms | Cancer | C00-C96 | CA9; |
C00-D49: Neoplasms | Breast cancer | C50 | CA9; |
C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; |