Plant Name: Phragmites australis
Taxonomic Information:
Plant ID: NPO127
Plant Latin Name: Phragmites australis
Taxonomy Genus: Phragmites
Taxonomy Family: Poaceae
Plant External Links:
NCBI TaxonomyDB:
29695
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Thailand; IndiaTraditional Medicine System:
Indian FolkMedicinal Functions:
Antiasthmatic; Antidote; Antiemetic; Antitussive; Depurative; Diuretic; Febrifuge; Lithontripic; Miscellany; Refrigerant; Sialagogue; Stomachic; Styptic
Geographical Distribution:
Thailand; India
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TDP1; ALDH1A1; BRCA1; CD38; | |
| CA2; CA14; CA7; CA5A; CA6; CA12; CA9; CA1; | |
| SLCO1B3; | |
| PAX8; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | BRCA1 | Breast cancer type 1 susceptibility protein | P38398 | CHEMBL5990 |
| Enzyme_unclassified | CD38 | Lymphocyte differentiation antigen CD38 | P28907 | CHEMBL4660 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| Unclassified | PAX8 | Paired box protein Pax-8 | Q06710 | CHEMBL2362980 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.282E-08 | 4.969E-05 | BRCA1, CA1, CA12, CA2, CA5A, CA6, CA7, CA9 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 1.463E-06 | 2.450E-03 | CA2, CA7 |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 7.305E-06 | 9.942E-03 | CA1, CA2 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 4.019E-23 | 8.751E-19 | CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.098E-18 | 1.195E-14 | CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.428E-16 | 6.217E-13 | CA1, CA12, CA2, CA5A, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:2001225; regulation of chloride transport | 2.188E-05 | 2.802E-02 | CA2, CA7 |
| BP | GO:0023052; signaling | GO:0032230; positive regulation of synaptic transmission, GABAergic | 3.788E-05 | 4.341E-02 | CA2, CA7 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 1.149E-22 | 2.527E-21 | CA12, CA1, CA2, CA5A, CA7, CA6, CA9, CA14 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.100E-03 | 1.210E-02 | CA2, SLCO1B3 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04972 | Pancreatic secretion | 1.998E-03 | 1.465E-02 | CA2, CD38 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04966 | Collecting duct acid secretion | 1.874E-02 | 6.322E-02 | CA2 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 1.599E-02 | 6.322E-02 | CA2 |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 2.012E-02 | 6.322E-02 | PAX8 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00760 | Nicotinate and nicotinamide metabolism | 2.012E-02 | 6.322E-02 | CD38 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04971 | Gastric acid secretion | 5.059E-02 | 1.012E-01 | CA2 |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03460 | Fanconi anemia pathway | 3.648E-02 | 1.003E-01 | BRCA1 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 4.457E-02 | 1.012E-01 | ALDH1A1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
