CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF;
Enzyme_unclassified	ALPI; RECQL; TDP1; HPGD; HSD11B1; AKR1B10; AKR1B1; ALDH1A1; POLB;
Hydrolase	GAA;
Lyase	CA2; CA1; CA12; CA9; CA7; CA3; CA14; CA5B; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Lysine demethylase	KDM4E;
Transferase	FUT7;
Unclassified	LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALPI	Intestinal alkaline phosphatase	P09923	CHEMBL5573
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016311; dephosphorylation	3.389E-07	5.677E-04	ACP1, ALPI, CA3, POLB, PTPN1, PTPN2, PTPRF
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.968E-06	8.209E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	7.968E-06	8.209E-03	GPBAR1, NR1H4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.744E-22	2.988E-18	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.030E-21	3.497E-17	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.141E-11	3.106E-08	ALPI, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, NR1H4, PTPN1, RORC
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.028E-29	1.095E-24	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0016791; phosphatase activity	4.916E-06	5.947E-03	ACP1, ALPI, CA3, PTPN1, PTPN2, PTPRF
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	7.968E-06	8.209E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	3.972E-05	3.089E-02	CA1, CA2

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.103E-28	1.148E-26	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.467E-05	2.714E-04	AKR1B10, GAA, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1.510E-03	9.313E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.194E-03	8.834E-03	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	4.009E-03	1.854E-02	AKR1B10, AKR1B1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.233E-04	2.754E-03	PTPN1, ACP1, PTPRF
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6.144E-04	5.684E-03	CA2, CA4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	5.753E-03	2.365E-02	CA2, NR1H4
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.312E-02	4.855E-02	PTPN1, PTPRF
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.949E-03	1.558E-02	HSD11B1, FUT7, AKR1B10, GAA, ALDH1A1, AKR1B1, ALPI

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Sideritis hirsuta

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities