CMAUP Plant Collective Molecular Activities

Plant Name: Rapanea neurophylla

Taxonomic Information:

Plant ID: NPO12633
Plant Latin Name: Rapanea neurophylla
Taxonomy Genus: Rapanea
Taxonomy Family: Primulaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; FAAH; TERT; ALOX12; ALOX15; USP2; POLB;
Hydrolase	GAA;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Oxidoreductase	ALOX5;
Bromodomain	KAT2B;
Transferase	XIAP;
Unclassified	MPEG1; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Bromodomain	KAT2B	Histone acetyltransferase PCAF	Q92831	CHEMBL5500
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	FAAH	Anandamide amidohydrolase	O00519	CHEMBL2243
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transferase	XIAP	Inhibitor of apoptosis protein 3	P98170	CHEMBL4198
Unclassified	MPEG1	Macrophage-expressed gene 1 protein	Q2M385	CHEMBL3414409
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	3.148E-07	1.714E-03	ALOX12, ALOX15, ALOX5
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	7.290E-07	1.764E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	7.290E-07	1.764E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	2.186E-06	2.975E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	2.186E-06	2.975E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	2.507E-06	3.211E-03	ALOX12, ALOX15, ALOX5
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	7.279E-06	5.716E-03	ALOX12, ALOX15
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	7.279E-06	5.716E-03	PPARA, PPARG
MF	GO:0005488; binding	GO:0008134; transcription factor binding	7.350E-06	5.716E-03	KAT2B, MAPK1, PPARA, PPARD, PPARG, TERT
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	6.591E-06	5.716E-03	ALOX5, FABP5, KAT2B, MAPK1, POLB, PPARA, PPARD, PPARG, TERT, USP2, XIAP
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	9.921E-06	6.516E-03	KAT2B, PPARA, PPARD, PPARG
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.017E-05	6.516E-03	PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	1.091E-05	6.601E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	1.091E-05	6.601E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	1.366E-05	8.039E-03	ALOX12, ALOX15, FAAH

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.984E-07	3.283E-05	FABP5, PPARG, PPARA, PPARD
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.097E-06	1.153E-04	ALOX5, ALOX15, MAPK1, ALOX12
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.870E-05	6.858E-04	ALOX5, ALOX15, ALOX12
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	5.641E-05	1.551E-03	POLB, KAT2B, TERT, XIAP
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	1.282E-04	2.820E-03	ALOX5, XIAP, MAPK1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.965E-04	4.659E-03	XIAP, MAPK1, PPARG, PPARD
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	6.490E-04	8.924E-03	POLB, KAT2B, MAPK1
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	2.724E-04	4.659E-03	MAPK1, PPARG
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.056E-03	1.291E-02	MAPK1, PPARD
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	3.268E-03	3.595E-02	FAAH, MAPK1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5;
J00-J99: Diseases of the respiratory system	Asthma	J45	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases