Plant Name: Swertia corymbosa
Taxonomic Information:
Plant ID: NPO12616
Plant Latin Name: Swertia corymbosa
Taxonomy Genus: Swertia
Taxonomy Family: Gentianaceae
Plant External Links:
NCBI TaxonomyDB:
1460259
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| PTPN1; PTPN2; CDC25B; | |
| PLA2G1B; AKR1B10; POLB; | |
| NR1H4; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 4.502E-07 | 4.901E-03 | GPBAR1, NR1H4 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 8.514E-07 | 4.901E-03 | NR1H4, PTPN1, PTPN2 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 9.002E-07 | 4.901E-03 | PTPN1, PTPN2 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 4.502E-07 | 4.901E-03 | GPBAR1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0016311; dephosphorylation | 3.058E-06 | 1.110E-02 | CDC25B, POLB, PTPN1, PTPN2 |
| MF | GO:0005488; binding | GO:0032052; bile acid binding | 5.396E-06 | 1.678E-02 | NR1H4, PLA2G1B |
| BP | GO:0009987; cellular process | GO:1903897; regulation of PERK-mediated unfolded protein response | 6.743E-06 | 1.710E-02 | PTPN1, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 7.178E-06 | 1.710E-02 | CDC25B, PTPN1, PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0004725; protein tyrosine phosphatase activity | 7.854E-06 | 1.710E-02 | CDC25B, PTPN1, PTPN2 |
| BP | GO:0009987; cellular process | GO:1900103; positive regulation of endoplasmic reticulum unfolded protein response | 1.168E-05 | 2.312E-02 | PTPN1, PTPN2 |
| BP | GO:0009987; cellular process | GO:0010804; negative regulation of tumor necrosis factor-mediated signaling pathway | 2.841E-05 | 5.156E-02 | NR1H4, PTPN2 |
| BP | GO:0009987; cellular process | GO:0001959; regulation of cytokine-mediated signaling pathway | 3.443E-05 | 5.747E-02 | NR1H4, PTPN1, PTPN2 |
| MF | GO:0005488; binding | GO:0030971; receptor tyrosine kinase binding | 2.286E-04 | 1.478E-01 | PTPN1, PTPN2 |
| CC | GO:0044464; cell part | GO:0097443; sorting endosome | 2.483E-03 | 3.888E-01 | PTPN1 |
| CC | GO:0043226; organelle | GO:0005876; spindle microtubule | 2.174E-02 | 1.000E+00 | POLB |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 2.458E-02 | 1.000E+00 | CDC25B, NR1H4, POLB, PTPN2 |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 2.751E-02 | 1.000E+00 | AKR1B10, CDC25B, PLA2G1B, PTPN1, PTPN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00592 | alpha-Linolenic acid metabolism | 9.958E-03 | 5.805E-02 | PLA2G1B |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.154E-02 | 5.805E-02 | PLA2G1B |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 1.431E-02 | 5.805E-02 | AKR1B10 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.194E-02 | 5.805E-02 | AKR1B10 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 1.273E-02 | 5.805E-02 | AKR1B10 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04975 | Fat digestion and absorption | 1.629E-02 | 5.805E-02 | PLA2G1B |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.313E-02 | 5.805E-02 | POLB |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 2.336E-02 | 6.332E-02 | AKR1B10 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 2.454E-02 | 6.332E-02 | PLA2G1B |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00565 | Ether lipid metabolism | 1.786E-02 | 5.805E-02 | PLA2G1B |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | CDC25B; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
