CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF; CDC25B;
Enzyme_unclassified	RECQL; PLA2G1B; HPGD; HSD11B1; AKR1B10; HSD17B10; ALDH1A1; POLB;
Miscellaneous ion channel	BCL2;
Protein Kinase	LCK; LIMK1;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Cysteine protease	CASP1; CASP7;
Unclassified	MCL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392

Showing 1 to 10 of 22 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	7.849E-08	3.972E-04	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0009987; cellular process	GO:2001244; positive regulation of intrinsic apoptotic signaling pathway	4.457E-07	1.417E-03	BCL2, LCK, MCL1, PTPN2
BP	GO:0019740; nitrogen utilization	GO:0006808; regulation of nitrogen utilization	3.712E-06	5.389E-03	BCL2, NR1H4
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	3.712E-06	5.389E-03	GPBAR1, NR1H4
BP	GO:0002376; immune system process	GO:0030217; T cell differentiation	4.424E-06	5.723E-03	BCL2, LCK, PTPN2, RORC
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	7.420E-06	8.503E-03	PTPN1, PTPN2
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	3.712E-06	5.389E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0003824; catalytic activity	9.001E-06	9.533E-03	ACP1, AKR1B10, ALDH1A1, CASP1, CASP7, CDC25B, HPGD, HSD11B1, HSD17B10, LCK, LIMK1, PLA2G1B, POLB, PTPN1, PTPN2, PTPRF, RECQL
MF	GO:0003824; catalytic activity	GO:0016616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	9.193E-06	9.533E-03	AKR1B10, HPGD, HSD11B1, HSD17B10
MF	GO:0005488; binding	GO:0051434; BH3 domain binding	1.236E-05	1.223E-02	BCL2, MCL1

Showing 1 to 10 of 11 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	6.671E-04	1.579E-02	BCL2, PTPN2, MCL1
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	4.651E-03	4.128E-02	LCK, BCL2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	7.119E-05	5.054E-03	PTPN1, ACP1, PTPRF
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	4.690E-04	1.579E-02	CASP7, BCL2, MCL1
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	1.011E-02	6.528E-02	PTPN1, PTPRF
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	1.425E-03	2.351E-02	BCL2, CASP1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.656E-03	2.351E-02	CASP7, CASP1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	4.050E-03	4.108E-02	BCL2, CDC25B, MCL1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	3.053E-03	3.613E-02	CASP7, CASP1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	6.332E-03	4.995E-02	PTPN1, PTPRF

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
C00-D49: Neoplasms	Prostate cancer	C61	BCL2;
C00-D49: Neoplasms	Multiple myeloma	C90	BCL2;
C00-D49: Neoplasms	Cancer	C00-C96	MCL1; CDC25B; BCL2;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
C00-D49: Neoplasms	Breast cancer	C50	BCL2;
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2;
C00-D49: Neoplasms	Leukemia	C90-C95	BCL2;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	LCK;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Lonicera korolkowii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities