Plant Name: Euphorbia royleana
Taxonomic Information:
Plant ID: NPO12595
Plant Latin Name: Euphorbia royleana
Taxonomy Genus: Euphorbia
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
1130020
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
China; IndiaTraditional Medicine System:
TCM; Unani; AyurvedaGeographical Distribution:
India; China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| CA7; CA9; CA12; | |
| PPARA; PPARD; | |
| PTGS1; | |
| GFER; ALDH1A1; HSD17B10; IDO1; | |
| CASP7; CASP1; | |
| TLR2; | |
| ABCB1; | |
| FABP3; LMNA; FABP2; FABP4; FABP5; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP1A2; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | IDO1 | Indoleamine 2,3-dioxygenase | P14902 | CHEMBL4685 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 1.042E-08 | 7.566E-05 | FABP2, FABP3, FABP4, FABP5 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 4.285E-07 | 7.775E-04 | CA12, CA7, CA9 |
| BP | GO:0032501; multicellular organismal process | GO:0001816; cytokine production | 1.457E-06 | 1.586E-03 | CASP1, FABP4, IDO1, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0050727; regulation of inflammatory response | 1.930E-06 | 1.827E-03 | CASP1, FABP4, IDO1, PPARA, PPARD, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0033993; response to lipid | 5.014E-06 | 4.043E-03 | CA9, CASP1, CYP1A2, FABP3, IDO1, PPARD, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 5.483E-06 | 4.264E-03 | CASP1, LMNA, PPARA, PPARD, TLR2 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 6.631E-06 | 4.658E-03 | CA12, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006631; fatty acid metabolic process | 1.049E-05 | 6.343E-03 | CYP1A2, FABP3, PPARA, PPARD, PTGS1 |
| BP | GO:0051704; multi-organism process | GO:0002237; response to molecule of bacterial origin | 1.049E-05 | 6.343E-03 | CASP1, CYP1A2, IDO1, PPARD, TLR2 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.224E-05 | 7.201E-03 | CA12, CA7, CA9 |
| MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 5.571E-05 | 2.696E-02 | FABP3, PPARD |
| MF | GO:0003824; catalytic activity | GO:0016491; oxidoreductase activity | 7.022E-05 | 3.186E-02 | ALDH1A1, CYP1A2, GFER, HSD17B10, IDO1, PTGS1 |
| MF | GO:0003824; catalytic activity | GO:0097200; cysteine-type endopeptidase activity involved in execution phase of apoptosis | 7.890E-05 | 3.506E-02 | CASP1, CASP7 |
| MF | GO:0005488; binding | GO:0048037; cofactor binding | 1.088E-04 | 4.387E-02 | ALDH1A1, CYP1A2, GFER, IDO1, PTGS1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 5.037E-11 | 2.921E-09 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 5.763E-07 | 1.671E-05 | CA12, CA7, CA9 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 2.170E-05 | 4.196E-04 | CASP7, CASP1, TLR2 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 7.243E-04 | 1.050E-02 | CYP1A2, IDO1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.416E-03 | 1.643E-02 | FABP4, PTGS1 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.903E-03 | 1.839E-02 | CYP1A2, ALDH1A1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 2.524E-03 | 2.091E-02 | CASP7, CASP1 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 6.417E-03 | 4.135E-02 | CYP1A2, ALDH1A1, HSD17B10, IDO1, PTGS1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 8.511E-03 | 4.936E-02 | CASP7, LMNA |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 4.991E-03 | 3.618E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9; |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA9; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9; |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
