Plant Name: Atractylodes chinensis
Taxonomic Information:
Plant ID: NPO12584
Plant Latin Name: Atractylodes chinensis
Taxonomy Genus: Atractylodes
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
69404
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
South Korea; ChinaTraditional Medicine System:
TCMGeographical Distribution:
South Korea; China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| CA2; | |
| ALOX15; | |
| CASP7; CASP1; | |
| HIF1A; TP53; | |
| XDH; | |
| SMN1;SMN2; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 1.187E-05 | 3.520E-02 | CASP1, CASP7, XDH |
| BP | GO:0050896; response to stimulus | GO:0010038; response to metal ion | 2.198E-05 | 3.520E-02 | ALOX15, CA2, HIF1A, TP53 |
| BP | GO:0009987; cellular process | GO:0071310; cellular response to organic substance | 2.199E-05 | 3.520E-02 | ALOX15, CASP1, CASP7, HIF1A, TP53, TSHR |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 2.425E-05 | 3.520E-02 | HIF1A, LMNA, TP53 |
| MF | GO:0003824; catalytic activity | GO:0097200; cysteine-type endopeptidase activity involved in execution phase of apoptosis | 2.292E-05 | 3.520E-02 | CASP1, CASP7 |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 8.217E-06 | 3.520E-02 | ALOX15, CA2, CASP1, CASP7, HIF1A, LMNA, SMN1, SMN2, TP53, XDH |
| CC | GO:0043226; organelle | GO:0097504; Gemini of coiled bodies | 1.940E-05 | 3.520E-02 | SMN1, SMN2 |
| CC | GO:0032991; macromolecular complex | GO:0032797; SMN complex | 2.292E-05 | 3.520E-02 | SMN1, SMN2 |
| CC | GO:0044464; cell part | GO:0034719; SMN-Sm protein complex | 4.489E-05 | 4.443E-02 | SMN1, SMN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 5.316E-05 | 3.828E-03 | CASP7, LMNA, TP53 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05014 | Amyotrophic lateral sclerosis (ALS) | 3.455E-04 | 9.647E-03 | CASP1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 4.020E-04 | 9.647E-03 | CASP7, CASP1 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 5.963E-04 | 1.073E-02 | TP53, HIF1A |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 7.466E-04 | 1.075E-02 | CASP7, CASP1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.833E-03 | 2.200E-02 | TP53, HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 5.309E-03 | 4.247E-02 | TP53, HIF1A |
| 09120 Genetic Information Processing | 09122 Translation | hsa03013 | RNA transport | 3.843E-03 | 3.459E-02 | SMN2, SMN1 |
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 9.313E-03 | 6.705E-02 | CA2 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 2.747E-03 | 2.826E-02 | XDH |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
